Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronil
Fipronil is a phenylpyrazole pesticide that is used in both residential and agricultural applications. Fipronil is detected in run-off and water systems that are near areas in which the pesticide has been applied. The pesticide acts to antagonize gamma aminobutyric acid receptors, leading to over-ex...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340920312956 |
| _version_ | 1818644043859492864 |
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| author | Ashley Eadie Isabel Cristina Vásquez Xuefang Liang Xiaohong Wang Christopher L. Souders, II Jana El Chehouri Rohit Hoskote April Feswick Andrew M. Cowie Jennifer R. Loughery Christopher J. Martyniuk |
| author_facet | Ashley Eadie Isabel Cristina Vásquez Xuefang Liang Xiaohong Wang Christopher L. Souders, II Jana El Chehouri Rohit Hoskote April Feswick Andrew M. Cowie Jennifer R. Loughery Christopher J. Martyniuk |
| author_sort | Ashley Eadie |
| collection | DOAJ |
| description | Fipronil is a phenylpyrazole pesticide that is used in both residential and agricultural applications. Fipronil is detected in run-off and water systems that are near areas in which the pesticide has been applied. The pesticide acts to antagonize gamma aminobutyric acid receptors, leading to over-excitation in the central nervous system. Fipronil has relatively high toxicity to fish, but the mechanisms underlying the toxicity are not well understood in embryonic stages. Zebrafish embryos were exposed to a single concentration of fipronil for 48 h at ∼3-4 h-post-fertilization. Following a 7-day depuration phase, transcriptome and behavioral analyses were conducted. Transcriptomics identified neural processes as those differentially expressed with different doses of fipronil (0.2 µg, 200 µg and 2 mg fipronil/L). Gene networks associated with astrocyte differentiation, myelination, neural tube development, brain stem response, innervation, nerve regeneration, astrocyte differentiation, among other pathways were altered with exposure. In addition, miRNA-related events are disrupted by fipronil exposure and genes associated with primary or pri-miRNA processing were increased in larval fish exposed to the pesticide. These data present putative mechanisms associated with neurological impacts at later ages of zebrafish. This is important because it is not clear how early exposure to pesticides like fipronil affect central nervous system function and organisms later in life. |
| first_indexed | 2024-12-17T00:08:35Z |
| format | Article |
| id | doaj.art-150003de66084bd99447edfeae2f250a |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-17T00:08:35Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-150003de66084bd99447edfeae2f250a2022-12-21T22:10:53ZengElsevierData in Brief2352-34092020-12-0133106413Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronilAshley Eadie0Isabel Cristina Vásquez1Xuefang Liang2Xiaohong Wang3Christopher L. Souders, II4Jana El Chehouri5Rohit Hoskote6April Feswick7Andrew M. Cowie8Jennifer R. Loughery9Christopher J. Martyniuk10Department of Biology, University of New Brunswick, Saint John, New Brunswick, E2L 4L5, CanadaDepartamento de Ciencias Fisiológicas, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá D.C., ColombiaSchool of Ecology and Environment, Inner Mongolia University, Hohhot, Inner Mongolia, 010021, People's Republic of ChinaDepartment of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32611 USADepartment of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32611 USADepartment of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32611 USADepartment of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32611 USADepartment of Biology, University of New Brunswick, Saint John, New Brunswick, E2L 4L5, CanadaDepartment of Biology, University of New Brunswick, Saint John, New Brunswick, E2L 4L5, CanadaDepartment of Biology, University of New Brunswick, Saint John, New Brunswick, E2L 4L5, CanadaDepartment of Biology, University of New Brunswick, Saint John, New Brunswick, E2L 4L5, Canada; Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32611 USA; Canadian Rivers Institute; Corresponding authors.Fipronil is a phenylpyrazole pesticide that is used in both residential and agricultural applications. Fipronil is detected in run-off and water systems that are near areas in which the pesticide has been applied. The pesticide acts to antagonize gamma aminobutyric acid receptors, leading to over-excitation in the central nervous system. Fipronil has relatively high toxicity to fish, but the mechanisms underlying the toxicity are not well understood in embryonic stages. Zebrafish embryos were exposed to a single concentration of fipronil for 48 h at ∼3-4 h-post-fertilization. Following a 7-day depuration phase, transcriptome and behavioral analyses were conducted. Transcriptomics identified neural processes as those differentially expressed with different doses of fipronil (0.2 µg, 200 µg and 2 mg fipronil/L). Gene networks associated with astrocyte differentiation, myelination, neural tube development, brain stem response, innervation, nerve regeneration, astrocyte differentiation, among other pathways were altered with exposure. In addition, miRNA-related events are disrupted by fipronil exposure and genes associated with primary or pri-miRNA processing were increased in larval fish exposed to the pesticide. These data present putative mechanisms associated with neurological impacts at later ages of zebrafish. This is important because it is not clear how early exposure to pesticides like fipronil affect central nervous system function and organisms later in life.http://www.sciencedirect.com/science/article/pii/S2352340920312956Environmental toxicologyGene networkNeurotoxicityPesticideAgrochemical |
| spellingShingle | Ashley Eadie Isabel Cristina Vásquez Xuefang Liang Xiaohong Wang Christopher L. Souders, II Jana El Chehouri Rohit Hoskote April Feswick Andrew M. Cowie Jennifer R. Loughery Christopher J. Martyniuk Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronil Data in Brief Environmental toxicology Gene network Neurotoxicity Pesticide Agrochemical |
| title | Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronil |
| title_full | Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronil |
| title_fullStr | Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronil |
| title_full_unstemmed | Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronil |
| title_short | Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronil |
| title_sort | transcriptome network data in larval zebrafish danio rerio following exposure to the phenylpyrazole fipronil |
| topic | Environmental toxicology Gene network Neurotoxicity Pesticide Agrochemical |
| url | http://www.sciencedirect.com/science/article/pii/S2352340920312956 |
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