Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de caso
This case report describes the findings of a 45-year-old white woman from Brazil, who developed myalgia, fever and macular rash. She was diagnosed as having dengue, based on clinical manifestations and specific IgM titers. One week after the first symptoms of dengue, the patient developed muscle wea...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2004-03-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000100025 |
| _version_ | 1818366583470292992 |
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| author | Nilse Querino Santos Ana Cláudia B. Azoubel Antonio Alberto Lopes Gersonita Costa Aroldo Bacellar |
| author_facet | Nilse Querino Santos Ana Cláudia B. Azoubel Antonio Alberto Lopes Gersonita Costa Aroldo Bacellar |
| author_sort | Nilse Querino Santos |
| collection | DOAJ |
| description | This case report describes the findings of a 45-year-old white woman from Brazil, who developed myalgia, fever and macular rash. She was diagnosed as having dengue, based on clinical manifestations and specific IgM titers. One week after the first symptoms of dengue, the patient developed muscle weakness, followed by tetraplegia with areflexia, and respiratory insufficiency. The electromyography had evidence of demyelinating neuropathy and the cerebrospinal fluid showed albuminocytologic dissociation. These neurologic findings were consistent with the diagnosis of Guillain-Barré syndrome. The patient was treated with immunoglobulin and metylprednisolone. Mechanical ventilation was started one week after hospital admission and maintained for four weeks. After six weeks of hospitalization the patient was discharged from the hospital on wheel chair, presenting mild muscle weakness and loss of patellar and ankle reflexes. When the patient was seen at the outpatient service three weeks after hospital discharge she was able to walk with help. This case report suggests a possible association between dengue and Guillain-Barré syndrome.<br>Este relato de caso descreve os achados de uma mulher de 45 anos, branca, que desenvolveu mialgia, febre e eritema macular. Ela recebeu o diagnóstico de dengue, tomando por base os achados clínicos e títulos específicos de IgM. Uma semana depois do início dos primeiros sintomas de dengue, a paciente desenvolveu fraqueza muscular, tetraplegia e insuficiência respiratória. A eletromiografia mostrou evidência de uma neuropatia desmielinizante e o liquor apresentou quadro de dissociação albuminocitológica. Os achados neurológicos foram consistentes com o diagnóstico de síndrome de Guillain-Barré. A paciente foi tratada com imunoglobulina e metilprednisolona. Ventilação mecânica foi iniciada uma semana após a admissão hospitalar, sendo mantida por quatro semanas. Após seis semanas de internamento a paciente teve alta em cadeira de rodas, apresentando fraqueza muscular e perda dos reflexos patelar e aquileu. Quando a paciente foi vista no ambulatório, três semanas após a alta hospitalar, ela já era capaz de andar com ajuda do acompanhante. Este relato de caso sugere uma possível associação entre dengue e síndrome de Guillain-Barré. |
| first_indexed | 2024-12-13T22:38:28Z |
| format | Article |
| id | doaj.art-1500fc6ad6324519a8441e8d16491060 |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-12-13T22:38:28Z |
| publishDate | 2004-03-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-1500fc6ad6324519a8441e8d164910602022-12-21T23:28:54ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272004-03-0162114414610.1590/S0004-282X2004000100025Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de casoNilse Querino SantosAna Cláudia B. AzoubelAntonio Alberto LopesGersonita CostaAroldo BacellarThis case report describes the findings of a 45-year-old white woman from Brazil, who developed myalgia, fever and macular rash. She was diagnosed as having dengue, based on clinical manifestations and specific IgM titers. One week after the first symptoms of dengue, the patient developed muscle weakness, followed by tetraplegia with areflexia, and respiratory insufficiency. The electromyography had evidence of demyelinating neuropathy and the cerebrospinal fluid showed albuminocytologic dissociation. These neurologic findings were consistent with the diagnosis of Guillain-Barré syndrome. The patient was treated with immunoglobulin and metylprednisolone. Mechanical ventilation was started one week after hospital admission and maintained for four weeks. After six weeks of hospitalization the patient was discharged from the hospital on wheel chair, presenting mild muscle weakness and loss of patellar and ankle reflexes. When the patient was seen at the outpatient service three weeks after hospital discharge she was able to walk with help. This case report suggests a possible association between dengue and Guillain-Barré syndrome.<br>Este relato de caso descreve os achados de uma mulher de 45 anos, branca, que desenvolveu mialgia, febre e eritema macular. Ela recebeu o diagnóstico de dengue, tomando por base os achados clínicos e títulos específicos de IgM. Uma semana depois do início dos primeiros sintomas de dengue, a paciente desenvolveu fraqueza muscular, tetraplegia e insuficiência respiratória. A eletromiografia mostrou evidência de uma neuropatia desmielinizante e o liquor apresentou quadro de dissociação albuminocitológica. Os achados neurológicos foram consistentes com o diagnóstico de síndrome de Guillain-Barré. A paciente foi tratada com imunoglobulina e metilprednisolona. Ventilação mecânica foi iniciada uma semana após a admissão hospitalar, sendo mantida por quatro semanas. Após seis semanas de internamento a paciente teve alta em cadeira de rodas, apresentando fraqueza muscular e perda dos reflexos patelar e aquileu. Quando a paciente foi vista no ambulatório, três semanas após a alta hospitalar, ela já era capaz de andar com ajuda do acompanhante. Este relato de caso sugere uma possível associação entre dengue e síndrome de Guillain-Barré.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000100025síndrome de Guillain-BarrédengueradiculoneuriteGuillain-Barré syndromedengueradiculoneuritis |
| spellingShingle | Nilse Querino Santos Ana Cláudia B. Azoubel Antonio Alberto Lopes Gersonita Costa Aroldo Bacellar Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de caso Arquivos de Neuro-Psiquiatria síndrome de Guillain-Barré dengue radiculoneurite Guillain-Barré syndrome dengue radiculoneuritis |
| title | Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de caso |
| title_full | Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de caso |
| title_fullStr | Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de caso |
| title_full_unstemmed | Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de caso |
| title_short | Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de caso |
| title_sort | guillain barre syndrome in the course of dengue case report sindrome de guillain barre no curso de dengue relato de caso |
| topic | síndrome de Guillain-Barré dengue radiculoneurite Guillain-Barré syndrome dengue radiculoneuritis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000100025 |
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