Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sex
Background: Increased micronuclei (MNi) frequencies in human lymphocytes are an indicator of chromosome instability and could be influenced by different exogenous and endogenous factors. The increased exposure to environmental pollutants has led to the awareness of the necessity for constant monitor...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Annals of Human Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/03014460.2020.1714728 |
| _version_ | 1797685548907757568 |
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| author | Alfredo Santovito Claudio Gendusa |
| author_facet | Alfredo Santovito Claudio Gendusa |
| author_sort | Alfredo Santovito |
| collection | DOAJ |
| description | Background: Increased micronuclei (MNi) frequencies in human lymphocytes are an indicator of chromosome instability and could be influenced by different exogenous and endogenous factors. The increased exposure to environmental pollutants has led to the awareness of the necessity for constant monitoring of urban human populations. Aim: We evaluated the MNi frequency in a sample belonging to the non-occupationally exposed population of Turin (North-Western Italy). A possible effect of body mass index, age and sex on the genomic damage levels was also investigated. Subjects and Methods: The study included 150 subjects. MNi, nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) were scored in 1,000 lymphocytes per subject. Results: The MNi, NPBs and NBUDs average frequencies (‰ ± S.D.) were 7.19 ± 2.51, 1.65 ± 1.54 and 2.07 ± 1.76, respectively. Turin shows one of the highest MNi frequencies with respect to other Italian cities and European regions. A significant correlation was found between MNi, NPBs, NBUDs frequencies, age and body mass index. Conclusion: Baseline MNi frequency was established in a sample of a city, like Turin, exposed to high levels of environmental pollutants. We hope that the results of this study can be used as a stimulus for future biomonitoring programmes in other Italian and globally distributed cities. |
| first_indexed | 2024-03-12T00:46:44Z |
| format | Article |
| id | doaj.art-150108fdbd4c4c9399bfdff66932628c |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:46:44Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-150108fdbd4c4c9399bfdff66932628c2023-09-14T15:36:11ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332020-01-01471485410.1080/03014460.2020.17147281714728Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sexAlfredo Santovito0Claudio Gendusa1University of TurinUniversity of TurinBackground: Increased micronuclei (MNi) frequencies in human lymphocytes are an indicator of chromosome instability and could be influenced by different exogenous and endogenous factors. The increased exposure to environmental pollutants has led to the awareness of the necessity for constant monitoring of urban human populations. Aim: We evaluated the MNi frequency in a sample belonging to the non-occupationally exposed population of Turin (North-Western Italy). A possible effect of body mass index, age and sex on the genomic damage levels was also investigated. Subjects and Methods: The study included 150 subjects. MNi, nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) were scored in 1,000 lymphocytes per subject. Results: The MNi, NPBs and NBUDs average frequencies (‰ ± S.D.) were 7.19 ± 2.51, 1.65 ± 1.54 and 2.07 ± 1.76, respectively. Turin shows one of the highest MNi frequencies with respect to other Italian cities and European regions. A significant correlation was found between MNi, NPBs, NBUDs frequencies, age and body mass index. Conclusion: Baseline MNi frequency was established in a sample of a city, like Turin, exposed to high levels of environmental pollutants. We hope that the results of this study can be used as a stimulus for future biomonitoring programmes in other Italian and globally distributed cities.http://dx.doi.org/10.1080/03014460.2020.1714728environmental pollutionitalian populationgenomic damagegenotoxicology |
| spellingShingle | Alfredo Santovito Claudio Gendusa Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sex Annals of Human Biology environmental pollution italian population genomic damage genotoxicology |
| title | Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sex |
| title_full | Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sex |
| title_fullStr | Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sex |
| title_full_unstemmed | Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sex |
| title_short | Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sex |
| title_sort | micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in turin north italy contribution of body mass index age and sex |
| topic | environmental pollution italian population genomic damage genotoxicology |
| url | http://dx.doi.org/10.1080/03014460.2020.1714728 |
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