Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort
Abstract Background Numerous studies suggest that sex steroids might play a role in sex disparity observed in allergic diseases in adults. However, whether sex hormones influence allergic diseases in children remains unclear. The aim of the present study was to examine the association of sex steroid...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-023-04302-9 |
| _version_ | 1797451452524789760 |
|---|---|
| author | Yumiko Miyaji Kiwako Yamamoto-Hanada Limin Yang Mayako Saito-Abe Miori Sato Hidetoshi Mezawa Minaho Nishizato Masayuki Ochiai Shouichi Ohga Masako Oda Hiroshi Mitsubuchi Masayuki Shimono Reiko Suga Nathan Mise Makiko Sekiyama Shoji F. Nakayama Yukihiro Ohya the Japan Environment and Children’s Study (JECS) |
| author_facet | Yumiko Miyaji Kiwako Yamamoto-Hanada Limin Yang Mayako Saito-Abe Miori Sato Hidetoshi Mezawa Minaho Nishizato Masayuki Ochiai Shouichi Ohga Masako Oda Hiroshi Mitsubuchi Masayuki Shimono Reiko Suga Nathan Mise Makiko Sekiyama Shoji F. Nakayama Yukihiro Ohya the Japan Environment and Children’s Study (JECS) |
| author_sort | Yumiko Miyaji |
| collection | DOAJ |
| description | Abstract Background Numerous studies suggest that sex steroids might play a role in sex disparity observed in allergic diseases in adults. However, whether sex hormones influence allergic diseases in children remains unclear. The aim of the present study was to examine the association of sex steroid hormones with allergic disease in Japanese children. Methods The present cross-sectional study included 145 6-year-old children participating in a pilot birth cohort study in the Japan Environment and Children’s Study. Data on allergic diseases were obtained from questionnaires, and serum levels of sex steroid hormones and allergen-specific IgE were measured. Logistic regression was performed to evaluate the association of sex hormones with allergic diseases. Results After adjusted sex, amount of body fat at 6 years, parental history of allergic disease, and exposure to tobacco smoke, serum dehydroepiandrosterone sulfate level was significantly associated with reduced odds of any allergic disease (adjusted odds ratio, 0.58; 95% confidence interval, 0.36–0.93; P = 0.024) and serum follicle-stimulating hormone level was significantly associated with increased odds of any allergic disease (adjusted odds ratio, 2.04; 95% confidence interval, 1.01–4.11, P = 0.046). Dehydroepiandrosterone sulfate level showed a significant association with number of allergic diseases. Conclusions The current study findings suggest that sex hormones may play an important role in the development of allergic diseases in prepubertal children. |
| first_indexed | 2024-03-09T14:53:54Z |
| format | Article |
| id | doaj.art-15020ab68b6342568803a96f498f0564 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-09T14:53:54Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-15020ab68b6342568803a96f498f05642023-11-26T14:15:56ZengBMCBMC Pediatrics1471-24312023-09-012311810.1186/s12887-023-04302-9Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohortYumiko Miyaji0Kiwako Yamamoto-Hanada1Limin Yang2Mayako Saito-Abe3Miori Sato4Hidetoshi Mezawa5Minaho Nishizato6Masayuki Ochiai7Shouichi Ohga8Masako Oda9Hiroshi Mitsubuchi10Masayuki Shimono11Reiko Suga12Nathan Mise13Makiko Sekiyama14Shoji F. Nakayama15Yukihiro Ohya16the Japan Environment and Children’s Study (JECS)Allergy Center, National Center for Child Health and DevelopmentAllergy Center, National Center for Child Health and DevelopmentMedical Support Center for the Japan Environment and Children’s Study, National Research Institute for Child Health and DevelopmentAllergy Center, National Center for Child Health and DevelopmentAllergy Center, National Center for Child Health and DevelopmentMedical Support Center for the Japan Environment and Children’s Study, National Research Institute for Child Health and DevelopmentMedical Support Center for the Japan Environment and Children’s Study, National Research Institute for Child Health and DevelopmentDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu UniversityThe South Kyushu Okinawa Unit Center, Faculty of Life Sciences, Kumamoto UniversityDepartment of Neonatology, Kumamoto University HospitalRegional Center for Pilot Study of Japan Environment and Children’s Study, University of Occupational and Environmental HealthRegional Center for Pilot Study of Japan Environment and Children’s Study, University of Occupational and Environmental HealthDepartment of Environmental and Preventive Medicine, Jichi Medical UniversityJapan Environment and Children’s Study Programme Office, National Institute for Environmental StudiesJapan Environment and Children’s Study Programme Office, National Institute for Environmental StudiesAllergy Center, National Center for Child Health and DevelopmentAbstract Background Numerous studies suggest that sex steroids might play a role in sex disparity observed in allergic diseases in adults. However, whether sex hormones influence allergic diseases in children remains unclear. The aim of the present study was to examine the association of sex steroid hormones with allergic disease in Japanese children. Methods The present cross-sectional study included 145 6-year-old children participating in a pilot birth cohort study in the Japan Environment and Children’s Study. Data on allergic diseases were obtained from questionnaires, and serum levels of sex steroid hormones and allergen-specific IgE were measured. Logistic regression was performed to evaluate the association of sex hormones with allergic diseases. Results After adjusted sex, amount of body fat at 6 years, parental history of allergic disease, and exposure to tobacco smoke, serum dehydroepiandrosterone sulfate level was significantly associated with reduced odds of any allergic disease (adjusted odds ratio, 0.58; 95% confidence interval, 0.36–0.93; P = 0.024) and serum follicle-stimulating hormone level was significantly associated with increased odds of any allergic disease (adjusted odds ratio, 2.04; 95% confidence interval, 1.01–4.11, P = 0.046). Dehydroepiandrosterone sulfate level showed a significant association with number of allergic diseases. Conclusions The current study findings suggest that sex hormones may play an important role in the development of allergic diseases in prepubertal children.https://doi.org/10.1186/s12887-023-04302-9Allergic diseaseAsthmaAtopic dermatitisDehydroepiandrosterone sulfateFollicle-stimulating hormoneSex steroid hormone |
| spellingShingle | Yumiko Miyaji Kiwako Yamamoto-Hanada Limin Yang Mayako Saito-Abe Miori Sato Hidetoshi Mezawa Minaho Nishizato Masayuki Ochiai Shouichi Ohga Masako Oda Hiroshi Mitsubuchi Masayuki Shimono Reiko Suga Nathan Mise Makiko Sekiyama Shoji F. Nakayama Yukihiro Ohya the Japan Environment and Children’s Study (JECS) Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort BMC Pediatrics Allergic disease Asthma Atopic dermatitis Dehydroepiandrosterone sulfate Follicle-stimulating hormone Sex steroid hormone |
| title | Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort |
| title_full | Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort |
| title_fullStr | Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort |
| title_full_unstemmed | Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort |
| title_short | Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort |
| title_sort | sex steroid hormones and allergic diseases in children a pilot birth cohort study in the japan environment and children s study cohort |
| topic | Allergic disease Asthma Atopic dermatitis Dehydroepiandrosterone sulfate Follicle-stimulating hormone Sex steroid hormone |
| url | https://doi.org/10.1186/s12887-023-04302-9 |
| work_keys_str_mv | AT yumikomiyaji sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT kiwakoyamamotohanada sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT liminyang sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT mayakosaitoabe sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT miorisato sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT hidetoshimezawa sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT minahonishizato sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT masayukiochiai sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT shouichiohga sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT masakooda sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT hiroshimitsubuchi sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT masayukishimono sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT reikosuga sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT nathanmise sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT makikosekiyama sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT shojifnakayama sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT yukihiroohya sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort AT thejapanenvironmentandchildrensstudyjecs sexsteroidhormonesandallergicdiseasesinchildrenapilotbirthcohortstudyinthejapanenvironmentandchildrensstudycohort |