In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus
Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals, which has significant economic consequences in affected countries. As the currently available vaccines against FMD provide no protection until 4−7 days post-vaccination, the only alternative method...
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MDPI AG
2019-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/9/1723 |
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| author | Shi-Fang Li Mei-Jiao Gong Yue-Feng Sun Jun-Jun Shao Yong-Guang Zhang Hui-Yun Chang |
| author_facet | Shi-Fang Li Mei-Jiao Gong Yue-Feng Sun Jun-Jun Shao Yong-Guang Zhang Hui-Yun Chang |
| author_sort | Shi-Fang Li |
| collection | DOAJ |
| description | Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals, which has significant economic consequences in affected countries. As the currently available vaccines against FMD provide no protection until 4−7 days post-vaccination, the only alternative method to control the spread of FMD virus (FMDV) during outbreaks is the application of antiviral agents. Hence, it is important to identify effective antiviral agents against FMDV infection. In this study, we found that mizoribine has potent antiviral activity against FMDV replication in IBRS-2 cells. A time-of-drug-addition assay demonstrated that mizoribine functions at the early stage of replication. Moreover, mizoribine also showed antiviral effect on FMDV in vivo. In summary, these results revealed that mizoribine could be a potential antiviral drug against FMDV. |
| first_indexed | 2024-12-17T10:03:18Z |
| format | Article |
| id | doaj.art-1503e76c76ee473c903030e7763afbe4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-17T10:03:18Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1503e76c76ee473c903030e7763afbe42022-12-21T21:53:13ZengMDPI AGMolecules1420-30492019-05-01249172310.3390/molecules24091723molecules24091723In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease VirusShi-Fang Li0Mei-Jiao Gong1Yue-Feng Sun2Jun-Jun Shao3Yong-Guang Zhang4Hui-Yun Chang5State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, ChinaState Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, ChinaState Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, ChinaState Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, ChinaState Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, ChinaState Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, ChinaFoot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals, which has significant economic consequences in affected countries. As the currently available vaccines against FMD provide no protection until 4−7 days post-vaccination, the only alternative method to control the spread of FMD virus (FMDV) during outbreaks is the application of antiviral agents. Hence, it is important to identify effective antiviral agents against FMDV infection. In this study, we found that mizoribine has potent antiviral activity against FMDV replication in IBRS-2 cells. A time-of-drug-addition assay demonstrated that mizoribine functions at the early stage of replication. Moreover, mizoribine also showed antiviral effect on FMDV in vivo. In summary, these results revealed that mizoribine could be a potential antiviral drug against FMDV.https://www.mdpi.com/1420-3049/24/9/1723foot-and-mouth disease virusfoot-and-mouth diseasemizoribineantiviralin vivo |
| spellingShingle | Shi-Fang Li Mei-Jiao Gong Yue-Feng Sun Jun-Jun Shao Yong-Guang Zhang Hui-Yun Chang In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus Molecules foot-and-mouth disease virus foot-and-mouth disease mizoribine antiviral in vivo |
| title | In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus |
| title_full | In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus |
| title_fullStr | In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus |
| title_full_unstemmed | In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus |
| title_short | In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus |
| title_sort | in vitro and in vivo antiviral activity of mizoribine against foot and mouth disease virus |
| topic | foot-and-mouth disease virus foot-and-mouth disease mizoribine antiviral in vivo |
| url | https://www.mdpi.com/1420-3049/24/9/1723 |
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