Head and neck carcinoma in children: A clinicopathological study of 42 cases

Background/purpose: Cancer is an important part of the global burden of childhood diseases. Head and neck carcinoma in children is rare and related research is limited. This study aimed to investigate the clinicopathological features of childhood head and neck carcinoma. Materials and methods: Forty...

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Main Authors: Xin-Jia Cai, Zu-Nan Tang, Yu-Ping Liu, Xu Wang, Jia-Ying Bai, Xiao-Wen Guo, He-Yu Zhang, Jian-Yun Zhang, Tie-Jun Li
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Journal of Dental Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1991790223001228
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author Xin-Jia Cai
Zu-Nan Tang
Yu-Ping Liu
Xu Wang
Jia-Ying Bai
Xiao-Wen Guo
He-Yu Zhang
Jian-Yun Zhang
Tie-Jun Li
author_facet Xin-Jia Cai
Zu-Nan Tang
Yu-Ping Liu
Xu Wang
Jia-Ying Bai
Xiao-Wen Guo
He-Yu Zhang
Jian-Yun Zhang
Tie-Jun Li
author_sort Xin-Jia Cai
collection DOAJ
description Background/purpose: Cancer is an important part of the global burden of childhood diseases. Head and neck carcinoma in children is rare and related research is limited. This study aimed to investigate the clinicopathological features of childhood head and neck carcinoma. Materials and methods: Forty-two cases of childhood head and neck carcinoma treated in our institution were reviewed and analyzed. Results: Median age overall was 11 years. Twenty-three patients (54.8%) were male and 19 (45.2%) were female. Parotid gland location was most common (54.8%). Mucoepidermoid carcinoma and squamous cell carcinoma were the most common histological types (57.1% and 11.9%, respectively). Two patients had a history of bone marrow transplantation and two had a history of odontogenic keratocyst. The recurrence rate after treatment was 8.6%. Conclusion: Early diagnosis and treatment and close follow-up of childhood head and neck carcinoma are warranted to prevent recurrence and improve clinical outcome.
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spelling doaj.art-15051fa670a041db9ada459554b2baa62023-09-27T04:42:25ZengElsevierJournal of Dental Sciences1991-79022023-10-0118414861492Head and neck carcinoma in children: A clinicopathological study of 42 casesXin-Jia Cai0Zu-Nan Tang1Yu-Ping Liu2Xu Wang3Jia-Ying Bai4Xiao-Wen Guo5He-Yu Zhang6Jian-Yun Zhang7Tie-Jun Li8Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), Beijing, PR China; Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR ChinaDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR ChinaDepartment of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR ChinaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR ChinaDepartment of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR ChinaDepartment of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR ChinaCentral Laboratory, Peking University School and Hospital of Stomatology, Beijing, PR ChinaDepartment of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR China; Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), Beijing, PR China; Corresponding author. Department of Oral Pathology, Peking University School and Hospital of Stomatology, No. 22, Zhongguancun South Avenue, Haidian District, Beijing 100081, PR China.Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), Beijing, PR China; Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR China; Corresponding author. Department of Oral Pathology, Peking University School and Hospital of Stomatology, No. 22, Zhongguancun South Avenue, Haidian District, Beijing 100081, PR China.Background/purpose: Cancer is an important part of the global burden of childhood diseases. Head and neck carcinoma in children is rare and related research is limited. This study aimed to investigate the clinicopathological features of childhood head and neck carcinoma. Materials and methods: Forty-two cases of childhood head and neck carcinoma treated in our institution were reviewed and analyzed. Results: Median age overall was 11 years. Twenty-three patients (54.8%) were male and 19 (45.2%) were female. Parotid gland location was most common (54.8%). Mucoepidermoid carcinoma and squamous cell carcinoma were the most common histological types (57.1% and 11.9%, respectively). Two patients had a history of bone marrow transplantation and two had a history of odontogenic keratocyst. The recurrence rate after treatment was 8.6%. Conclusion: Early diagnosis and treatment and close follow-up of childhood head and neck carcinoma are warranted to prevent recurrence and improve clinical outcome.http://www.sciencedirect.com/science/article/pii/S1991790223001228Head and neck carcinomaMucoepidermoid carcinomaSquamous cell carcinomaChildren
spellingShingle Xin-Jia Cai
Zu-Nan Tang
Yu-Ping Liu
Xu Wang
Jia-Ying Bai
Xiao-Wen Guo
He-Yu Zhang
Jian-Yun Zhang
Tie-Jun Li
Head and neck carcinoma in children: A clinicopathological study of 42 cases
Journal of Dental Sciences
Head and neck carcinoma
Mucoepidermoid carcinoma
Squamous cell carcinoma
Children
title Head and neck carcinoma in children: A clinicopathological study of 42 cases
title_full Head and neck carcinoma in children: A clinicopathological study of 42 cases
title_fullStr Head and neck carcinoma in children: A clinicopathological study of 42 cases
title_full_unstemmed Head and neck carcinoma in children: A clinicopathological study of 42 cases
title_short Head and neck carcinoma in children: A clinicopathological study of 42 cases
title_sort head and neck carcinoma in children a clinicopathological study of 42 cases
topic Head and neck carcinoma
Mucoepidermoid carcinoma
Squamous cell carcinoma
Children
url http://www.sciencedirect.com/science/article/pii/S1991790223001228
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