The Entrapment of Somatostatin in a Lipid Formulation: Retarded Release and Free Radical Reactivity

The Entrapment of Somatostatin in a Lipid Formulation: Retarded Release and Free Radical Reactivity

The natural peptide somatostatin has hormonal and cytostatic effects exerted by the binding to specific receptors in various tissues. Therapeutic uses are strongly prevented by its very short biological half-life of 1–2 min due to enzymatic hydrolysis, therefore encapsulation methodologies are explo...

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Bibliographic Details
Main Authors: Anna Vita Larocca, Gianluca Toniolo, Silvia Tortorella, Marios G. Krokidis, Georgia Menounou, Giuseppe Di Bella, Chryssostomos Chatgilialoglu, Carla Ferreri
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
liposomal somatostatin
retarded delivery
free radicals
isomerization
trans lipid
peroxidation
Online Access:https://www.mdpi.com/1420-3049/24/17/3085

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