Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study
The GENCOV study aims to identify patient factors which affect COVID-19 severity and outcomes. Here, we aimed to evaluate patient characteristics, acute symptoms and their persistence, and associations with hospitalization. Participants were recruited at hospital sites across the Greater Toronto Are...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/8/1764 |
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| author | Gregory Morgan Selina Casalino Sunakshi Chowdhary Erika Frangione Chun Yiu Jordan Fung Simona Haller Elisa Lapadula Mackenzie Scott Dawit Wolday Juliet Young Saranya Arnoldo Navneet Aujla Erin Bearss Alexandra Binnie Yvonne Bombard Bjug Borgundvaag Laurent Briollais Marc Dagher Luke Devine Hanna Faghfoury Steven M. Friedman Anne-Claude Gingras Lee W. Goneau Zeeshan Khan Tony Mazzulli Shelley L. McLeod Romina Nomigolzar Abdul Noor Trevor J. Pugh David Richardson Harpreet Kaur Satnam Singh Jared Simpson Seth Stern Lisa Strug Ahmed Taher Jordan Lerner-Ellis Jennifer Taher |
| author_facet | Gregory Morgan Selina Casalino Sunakshi Chowdhary Erika Frangione Chun Yiu Jordan Fung Simona Haller Elisa Lapadula Mackenzie Scott Dawit Wolday Juliet Young Saranya Arnoldo Navneet Aujla Erin Bearss Alexandra Binnie Yvonne Bombard Bjug Borgundvaag Laurent Briollais Marc Dagher Luke Devine Hanna Faghfoury Steven M. Friedman Anne-Claude Gingras Lee W. Goneau Zeeshan Khan Tony Mazzulli Shelley L. McLeod Romina Nomigolzar Abdul Noor Trevor J. Pugh David Richardson Harpreet Kaur Satnam Singh Jared Simpson Seth Stern Lisa Strug Ahmed Taher Jordan Lerner-Ellis Jennifer Taher |
| author_sort | Gregory Morgan |
| collection | DOAJ |
| description | The GENCOV study aims to identify patient factors which affect COVID-19 severity and outcomes. Here, we aimed to evaluate patient characteristics, acute symptoms and their persistence, and associations with hospitalization. Participants were recruited at hospital sites across the Greater Toronto Area in Ontario, Canada. Patient-reported demographics, medical history, and COVID-19 symptoms and complications were collected through an intake survey. Regression analyses were performed to identify associations with outcomes including hospitalization and COVID-19 symptoms. In total, 966 responses were obtained from 1106 eligible participants (87% response rate) between November 2020 and May 2022. Increasing continuous age (aOR: 1.05 [95%CI: 1.01–1.08]) and BMI (aOR: 1.17 [95%CI: 1.10–1.24]), non-White/European ethnicity (aOR: 2.72 [95%CI: 1.22–6.05]), hypertension (aOR: 2.78 [95%CI: 1.22–6.34]), and infection by viral variants (aOR: 5.43 [95%CI: 1.45–20.34]) were identified as risk factors for hospitalization. Several symptoms including shortness of breath and fever were found to be more common among inpatients and tended to persist for longer durations following acute illness. Sex, age, ethnicity, BMI, vaccination status, viral strain, and underlying health conditions were associated with developing and having persistent symptoms. By improving our understanding of risk factors for severe COVID-19, our findings may guide COVID-19 patient management strategies by enabling more efficient clinical decision making. |
| first_indexed | 2024-03-10T23:30:21Z |
| format | Article |
| id | doaj.art-1506a59a12fb42399b492e89b9c90212 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T23:30:21Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1506a59a12fb42399b492e89b9c902122023-11-19T03:21:31ZengMDPI AGViruses1999-49152023-08-01158176410.3390/v15081764Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV StudyGregory Morgan0Selina Casalino1Sunakshi Chowdhary2Erika Frangione3Chun Yiu Jordan Fung4Simona Haller5Elisa Lapadula6Mackenzie Scott7Dawit Wolday8Juliet Young9Saranya Arnoldo10Navneet Aujla11Erin Bearss12Alexandra Binnie13Yvonne Bombard14Bjug Borgundvaag15Laurent Briollais16Marc Dagher17Luke Devine18Hanna Faghfoury19Steven M. Friedman20Anne-Claude Gingras21Lee W. Goneau22Zeeshan Khan23Tony Mazzulli24Shelley L. McLeod25Romina Nomigolzar26Abdul Noor27Trevor J. Pugh28David Richardson29Harpreet Kaur Satnam Singh30Jared Simpson31Seth Stern32Lisa Strug33Ahmed Taher34Jordan Lerner-Ellis35Jennifer Taher36Lunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaMount Sinai Academic Family Health Team, Mount Sinai Hospital, Toronto, ON M5T 3L9, CanadaDepartment of Critical Care, William Osler Health System, Etobicoke, ON M9V 1R8, CanadaLi Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON M5B 1A6, CanadaSchwartz/Reisman Emergency Medicine Institute, Sinai Health System, Toronto, ON M5G 2A2, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaDepartment of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, CanadaDivision of General Internal Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, CanadaFred A Litwin Family Centre in Genetic Medicine, University Health Network & Mount Sinai Hospital, Toronto, ON M5T 3H7, CanadaDepartment of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaDynacare Medical Laboratories, Brampton, ON L6T 5V1, CanadaMackenzie Health, Richmond Hill, ON L4C 4Z3, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, CanadaDepartment of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, CanadaMackenzie Health, Richmond Hill, ON L4C 4Z3, CanadaPathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, CanadaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, CanadaWilliam Osler Health System, Brampton, ON L6R 3J7, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaOntario Institute for Cancer Research, Toronto, ON M5G 0A3, CanadaMackenzie Health, Richmond Hill, ON L4C 4Z3, CanadaThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, CanadaMackenzie Health, Richmond Hill, ON L4C 4Z3, CanadaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, CanadaPathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, CanadaThe GENCOV study aims to identify patient factors which affect COVID-19 severity and outcomes. Here, we aimed to evaluate patient characteristics, acute symptoms and their persistence, and associations with hospitalization. Participants were recruited at hospital sites across the Greater Toronto Area in Ontario, Canada. Patient-reported demographics, medical history, and COVID-19 symptoms and complications were collected through an intake survey. Regression analyses were performed to identify associations with outcomes including hospitalization and COVID-19 symptoms. In total, 966 responses were obtained from 1106 eligible participants (87% response rate) between November 2020 and May 2022. Increasing continuous age (aOR: 1.05 [95%CI: 1.01–1.08]) and BMI (aOR: 1.17 [95%CI: 1.10–1.24]), non-White/European ethnicity (aOR: 2.72 [95%CI: 1.22–6.05]), hypertension (aOR: 2.78 [95%CI: 1.22–6.34]), and infection by viral variants (aOR: 5.43 [95%CI: 1.45–20.34]) were identified as risk factors for hospitalization. Several symptoms including shortness of breath and fever were found to be more common among inpatients and tended to persist for longer durations following acute illness. Sex, age, ethnicity, BMI, vaccination status, viral strain, and underlying health conditions were associated with developing and having persistent symptoms. By improving our understanding of risk factors for severe COVID-19, our findings may guide COVID-19 patient management strategies by enabling more efficient clinical decision making.https://www.mdpi.com/1999-4915/15/8/1764SARS-CoV-2COVID-19hospitalizationrisk factorsclinical characteristicssymptoms |
| spellingShingle | Gregory Morgan Selina Casalino Sunakshi Chowdhary Erika Frangione Chun Yiu Jordan Fung Simona Haller Elisa Lapadula Mackenzie Scott Dawit Wolday Juliet Young Saranya Arnoldo Navneet Aujla Erin Bearss Alexandra Binnie Yvonne Bombard Bjug Borgundvaag Laurent Briollais Marc Dagher Luke Devine Hanna Faghfoury Steven M. Friedman Anne-Claude Gingras Lee W. Goneau Zeeshan Khan Tony Mazzulli Shelley L. McLeod Romina Nomigolzar Abdul Noor Trevor J. Pugh David Richardson Harpreet Kaur Satnam Singh Jared Simpson Seth Stern Lisa Strug Ahmed Taher Jordan Lerner-Ellis Jennifer Taher Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study Viruses SARS-CoV-2 COVID-19 hospitalization risk factors clinical characteristics symptoms |
| title | Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study |
| title_full | Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study |
| title_fullStr | Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study |
| title_full_unstemmed | Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study |
| title_short | Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study |
| title_sort | characterizing risk factors for hospitalization and clinical characteristics in a cohort of covid 19 patients enrolled in the gencov study |
| topic | SARS-CoV-2 COVID-19 hospitalization risk factors clinical characteristics symptoms |
| url | https://www.mdpi.com/1999-4915/15/8/1764 |
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