Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression

Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression

Abstract Background Ubiquitin-specific protease 22 (USP22), a putative cancer stem cell marker, is frequently upregulated in cancers, and USP22 overexpression is associated with aggressive growth, metastasis, and therapy resistance in various human cancers including lung cancer. However, USP22 gene...

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Bibliographic Details
Main Authors: Ting Sun, Keqiang Zhang, Wendong Li, Yunze Liu, Rajendra P. Pangeni, Aimin Li, Leonidas Arvanitis, Dan J. Raz
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cell Communication and Signaling
Subjects:
USP22
AP2
ATF3
NSCLC
Transcriptional regulation
Cell proliferation
Online Access:https://doi.org/10.1186/s12964-022-00946-9

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