Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes
Existing evidence supports an association between chemerin levels and cardiovascular risk, while reduced thiol levels are linked to diabetes mellitus. It is hypothesized that chemerin may contribute to autonomic dysfunction and cardiovascular risk in type 2 diabetes mellitus (T2DM), potentially medi...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/11/3024 |
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| author | Yun-Ru Lai Chih-Cheng Huang Ben-Chung Cheng Wen-Chan Chiu Ting-Yin Lin Hui-Ching Chiang Chun-En Kuo Cheng-Hsien Lu |
| author_facet | Yun-Ru Lai Chih-Cheng Huang Ben-Chung Cheng Wen-Chan Chiu Ting-Yin Lin Hui-Ching Chiang Chun-En Kuo Cheng-Hsien Lu |
| author_sort | Yun-Ru Lai |
| collection | DOAJ |
| description | Existing evidence supports an association between chemerin levels and cardiovascular risk, while reduced thiol levels are linked to diabetes mellitus. It is hypothesized that chemerin may contribute to autonomic dysfunction and cardiovascular risk in type 2 diabetes mellitus (T2DM), potentially mediated by the antioxidant capacity of patients with well-controlled T2DM and prediabetes. Comprehensive cardiovascular autonomic testing and biomarker assessments were conducted for all participants. The severity of cardiovascular autonomic neuropathy (CAN) was evaluated using the composite autonomic scoring scale (CASS). A mediation model was employed to explore the potential relationships among chemerin levels, antioxidant capacity (indicated by thiol levels), and CAN severity (indicated by CASS values). A total of 184 participants were enrolled in this study, comprising 143 individuals with T2DM and 40 individuals with prediabetes. The findings reveal a significant negative association between thiols levels (r = −0.38, <i>p</i> < 0.0001) and the CASS values, while a positive association is observed between chemerin levels (r = 0.47, <i>p</i> < 0.0001) and the CASS values. Linear regression analysis identified chemerin and thiols as independent variables significantly associated with CASS values. Subsequent mediation analysis elucidated that thiols levels act as mediators in the relationship between elevated chemerin levels and an increased CASS value. This study shows that poor cardiovascular function, higher chemerin levels, and reduced antioxidant capacity coexist in individuals with T2DM and prediabetes. Mediation analysis suggests a pathophysiological link between high chemerin levels and low antioxidant capacity, adversely impacting CAN severity. |
| first_indexed | 2024-03-09T16:59:52Z |
| format | Article |
| id | doaj.art-1508e04ecbae4596bf240551fbf18d9b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T16:59:52Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1508e04ecbae4596bf240551fbf18d9b2023-11-24T14:31:12ZengMDPI AGBiomedicines2227-90592023-11-011111302410.3390/biomedicines11113024Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and PrediabetesYun-Ru Lai0Chih-Cheng Huang1Ben-Chung Cheng2Wen-Chan Chiu3Ting-Yin Lin4Hui-Ching Chiang5Chun-En Kuo6Cheng-Hsien Lu7Departments of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung City 83301, TaiwanDepartments of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung City 83301, TaiwanDepartments of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung City 83301, TaiwanDepartments of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung City 83301, TaiwanDepartments of Nursing, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung City 83301, TaiwanDepartments of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung City 83301, TaiwanDepartments of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City 83301, TaiwanDepartments of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung City 83301, TaiwanExisting evidence supports an association between chemerin levels and cardiovascular risk, while reduced thiol levels are linked to diabetes mellitus. It is hypothesized that chemerin may contribute to autonomic dysfunction and cardiovascular risk in type 2 diabetes mellitus (T2DM), potentially mediated by the antioxidant capacity of patients with well-controlled T2DM and prediabetes. Comprehensive cardiovascular autonomic testing and biomarker assessments were conducted for all participants. The severity of cardiovascular autonomic neuropathy (CAN) was evaluated using the composite autonomic scoring scale (CASS). A mediation model was employed to explore the potential relationships among chemerin levels, antioxidant capacity (indicated by thiol levels), and CAN severity (indicated by CASS values). A total of 184 participants were enrolled in this study, comprising 143 individuals with T2DM and 40 individuals with prediabetes. The findings reveal a significant negative association between thiols levels (r = −0.38, <i>p</i> < 0.0001) and the CASS values, while a positive association is observed between chemerin levels (r = 0.47, <i>p</i> < 0.0001) and the CASS values. Linear regression analysis identified chemerin and thiols as independent variables significantly associated with CASS values. Subsequent mediation analysis elucidated that thiols levels act as mediators in the relationship between elevated chemerin levels and an increased CASS value. This study shows that poor cardiovascular function, higher chemerin levels, and reduced antioxidant capacity coexist in individuals with T2DM and prediabetes. Mediation analysis suggests a pathophysiological link between high chemerin levels and low antioxidant capacity, adversely impacting CAN severity.https://www.mdpi.com/2227-9059/11/11/3024antioxidant capacitycardiovascular autonomic neuropathychemerincomposite autonomic scoring scaletype 2 diabetes and prediabetesthiol |
| spellingShingle | Yun-Ru Lai Chih-Cheng Huang Ben-Chung Cheng Wen-Chan Chiu Ting-Yin Lin Hui-Ching Chiang Chun-En Kuo Cheng-Hsien Lu Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes Biomedicines antioxidant capacity cardiovascular autonomic neuropathy chemerin composite autonomic scoring scale type 2 diabetes and prediabetes thiol |
| title | Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes |
| title_full | Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes |
| title_fullStr | Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes |
| title_full_unstemmed | Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes |
| title_short | Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes |
| title_sort | impacts of chemerin levels and antioxidant capacity on the severity of cardiovascular autonomic neuropathy in patients with type 2 diabetes and prediabetes |
| topic | antioxidant capacity cardiovascular autonomic neuropathy chemerin composite autonomic scoring scale type 2 diabetes and prediabetes thiol |
| url | https://www.mdpi.com/2227-9059/11/11/3024 |
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