The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in <named-content content-type="genus-species">Acinetobacter baumannii</named-content>: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in <named-content content-type="genus-species">Acinetobacter baumannii</named-content>: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

ABSTRACT The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical isolates now show high-level resistance due to mutations in gyrA (DNA gyrase) and parC (topoisomerase IV [t...

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Bibliographic Details
Main Authors: Edward Geisinger, Germán Vargas-Cuebas, Nadav J. Mortman, Sapna Syal, Yunfei Dai, Elizabeth L. Wainwright, David Lazinski, Stephen Wood, Zeyu Zhu, Jon Anthony, Tim van Opijnen, Ralph R. Isberg
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Acinetobacter
DNA gyrase
fitness
fluoroquinolone
prophage
antibiotic resistance
Online Access:https://journals.asm.org/doi/10.1128/mBio.01127-19

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