An Overview of Canine Inherited Neurological Disorders with Known Causal Variants
Hereditary neurological conditions documented in dogs encompass congenital, neonatal, and late-onset disorders, along with both progressive and non-progressive forms. In order to identify the causal variant of a disease, the main two approaches are genome-wide investigations and candidate gene inves...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/13/22/3568 |
| _version_ | 1797460376824053760 |
|---|---|
| author | Vlad Cocostîrc Anamaria Ioana Paștiu Dana Liana Pusta |
| author_facet | Vlad Cocostîrc Anamaria Ioana Paștiu Dana Liana Pusta |
| author_sort | Vlad Cocostîrc |
| collection | DOAJ |
| description | Hereditary neurological conditions documented in dogs encompass congenital, neonatal, and late-onset disorders, along with both progressive and non-progressive forms. In order to identify the causal variant of a disease, the main two approaches are genome-wide investigations and candidate gene investigation. Online Mendelian Inheritance in Animals currently lists 418 Mendelian disorders specific to dogs, of which 355 have their likely causal genetic variant identified. This review aims to summarize the current knowledge on the canine nervous system phenes and their genetic causal variant. It has been noted that the majority of these diseases have an autosomal recessive pattern of inheritance. Additionally, the dog breeds that are more prone to develop such diseases are the Golden Retriever, in which six inherited neurological disorders with a known causal variant have been documented, and the Belgian Shepherd, in which five such disorders have been documented. DNA tests can play a vital role in effectively managing and ultimately eradicating inherited diseases. |
| first_indexed | 2024-03-09T17:05:09Z |
| format | Article |
| id | doaj.art-150a88541702466da52de4de18f997e8 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T17:05:09Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-150a88541702466da52de4de18f997e82023-11-24T14:25:01ZengMDPI AGAnimals2076-26152023-11-011322356810.3390/ani13223568An Overview of Canine Inherited Neurological Disorders with Known Causal VariantsVlad Cocostîrc0Anamaria Ioana Paștiu1Dana Liana Pusta2Department of Genetics and Hereditary Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, RomaniaDepartment of Genetics and Hereditary Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, RomaniaDepartment of Genetics and Hereditary Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, RomaniaHereditary neurological conditions documented in dogs encompass congenital, neonatal, and late-onset disorders, along with both progressive and non-progressive forms. In order to identify the causal variant of a disease, the main two approaches are genome-wide investigations and candidate gene investigation. Online Mendelian Inheritance in Animals currently lists 418 Mendelian disorders specific to dogs, of which 355 have their likely causal genetic variant identified. This review aims to summarize the current knowledge on the canine nervous system phenes and their genetic causal variant. It has been noted that the majority of these diseases have an autosomal recessive pattern of inheritance. Additionally, the dog breeds that are more prone to develop such diseases are the Golden Retriever, in which six inherited neurological disorders with a known causal variant have been documented, and the Belgian Shepherd, in which five such disorders have been documented. DNA tests can play a vital role in effectively managing and ultimately eradicating inherited diseases.https://www.mdpi.com/2076-2615/13/22/3568canine inherited neurological diseasescausal variantMendelian disorders |
| spellingShingle | Vlad Cocostîrc Anamaria Ioana Paștiu Dana Liana Pusta An Overview of Canine Inherited Neurological Disorders with Known Causal Variants Animals canine inherited neurological diseases causal variant Mendelian disorders |
| title | An Overview of Canine Inherited Neurological Disorders with Known Causal Variants |
| title_full | An Overview of Canine Inherited Neurological Disorders with Known Causal Variants |
| title_fullStr | An Overview of Canine Inherited Neurological Disorders with Known Causal Variants |
| title_full_unstemmed | An Overview of Canine Inherited Neurological Disorders with Known Causal Variants |
| title_short | An Overview of Canine Inherited Neurological Disorders with Known Causal Variants |
| title_sort | overview of canine inherited neurological disorders with known causal variants |
| topic | canine inherited neurological diseases causal variant Mendelian disorders |
| url | https://www.mdpi.com/2076-2615/13/22/3568 |
| work_keys_str_mv | AT vladcocostirc anoverviewofcanineinheritedneurologicaldisorderswithknowncausalvariants AT anamariaioanapastiu anoverviewofcanineinheritedneurologicaldisorderswithknowncausalvariants AT danalianapusta anoverviewofcanineinheritedneurologicaldisorderswithknowncausalvariants AT vladcocostirc overviewofcanineinheritedneurologicaldisorderswithknowncausalvariants AT anamariaioanapastiu overviewofcanineinheritedneurologicaldisorderswithknowncausalvariants AT danalianapusta overviewofcanineinheritedneurologicaldisorderswithknowncausalvariants |