The aging process and its relation to periodontal conditions
Periodontal tissue destruction can cause complaints for sufferers. Inflammatory conditions of the gingiva, bleeding gums, and even tooth loss are clinical features of the destruction of the periodontal tissues. Periodontitis is an inflammatory disease involving the periodontal tissues. The prevalenc...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-06-01
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| Series: | Exploration of Immunology |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/ei/Article/100398 |
| _version_ | 1797778288465149952 |
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| author | Pitu Wulandari |
| author_facet | Pitu Wulandari |
| author_sort | Pitu Wulandari |
| collection | DOAJ |
| description | Periodontal tissue destruction can cause complaints for sufferers. Inflammatory conditions of the gingiva, bleeding gums, and even tooth loss are clinical features of the destruction of the periodontal tissues. Periodontitis is an inflammatory disease involving the periodontal tissues. The prevalence of periodontium destruction increases with aging. Changes in innate and adaptive immunity that occur in the elderly also play a role in the severity of periodontitis. “Inflammaging” is a chronic inflammatory state associated with old age in humans. Periodontitis contributes to inflammaging since periodontitis in the elderly is associated with increased markers of systemic inflammation. Age-related changes also affect neutrophil function, especially antimicrobial activity, so neutrophils may become more pathological. After infiltration into the tissue, neutrophils are equipped with several antimicrobial strategies to reduce the number of antigens. Phagocytosis is the ability of neutrophils to engulf and kill microbes, but neutrophil phagocytosis is weakened in the elderly. Age-related changes affecting neutrophils, macrophages, and T cells appear to promote pathogenic immune responses and contribute to the increased prevalence of periodontal disease in aging individuals. Proper regulation of the host immune response is critical in maintaining periodontal health. This paper aims to describe the aging process and its relation to periodontal conditions. |
| first_indexed | 2024-03-12T23:15:06Z |
| format | Article |
| id | doaj.art-150ae033e528430699d40db08ab52163 |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-03-12T23:15:06Z |
| publishDate | 2023-06-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-150ae033e528430699d40db08ab521632023-07-17T08:04:04ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552023-06-0133207216https://doi.org/10.37349/ei.2023.00098The aging process and its relation to periodontal conditionsPitu Wulandari0https://orcid.org/0000-0001-8337-2691Department of Periodontics, Faculty of Dentistry, Universitas Sumatera Utara, Medan 20155, IndonesiaPeriodontal tissue destruction can cause complaints for sufferers. Inflammatory conditions of the gingiva, bleeding gums, and even tooth loss are clinical features of the destruction of the periodontal tissues. Periodontitis is an inflammatory disease involving the periodontal tissues. The prevalence of periodontium destruction increases with aging. Changes in innate and adaptive immunity that occur in the elderly also play a role in the severity of periodontitis. “Inflammaging” is a chronic inflammatory state associated with old age in humans. Periodontitis contributes to inflammaging since periodontitis in the elderly is associated with increased markers of systemic inflammation. Age-related changes also affect neutrophil function, especially antimicrobial activity, so neutrophils may become more pathological. After infiltration into the tissue, neutrophils are equipped with several antimicrobial strategies to reduce the number of antigens. Phagocytosis is the ability of neutrophils to engulf and kill microbes, but neutrophil phagocytosis is weakened in the elderly. Age-related changes affecting neutrophils, macrophages, and T cells appear to promote pathogenic immune responses and contribute to the increased prevalence of periodontal disease in aging individuals. Proper regulation of the host immune response is critical in maintaining periodontal health. This paper aims to describe the aging process and its relation to periodontal conditions.https://www.explorationpub.com/Journals/ei/Article/100398periodontalinflammationagingimmunityperiodontitis |
| spellingShingle | Pitu Wulandari The aging process and its relation to periodontal conditions Exploration of Immunology periodontal inflammation aging immunity periodontitis |
| title | The aging process and its relation to periodontal conditions |
| title_full | The aging process and its relation to periodontal conditions |
| title_fullStr | The aging process and its relation to periodontal conditions |
| title_full_unstemmed | The aging process and its relation to periodontal conditions |
| title_short | The aging process and its relation to periodontal conditions |
| title_sort | aging process and its relation to periodontal conditions |
| topic | periodontal inflammation aging immunity periodontitis |
| url | https://www.explorationpub.com/Journals/ei/Article/100398 |
| work_keys_str_mv | AT pituwulandari theagingprocessanditsrelationtoperiodontalconditions AT pituwulandari agingprocessanditsrelationtoperiodontalconditions |