The nucleolus: a paradigm for cell proliferation and aging
The nucleolus is the cellular site of ribosome biosynthesis. At this site, active ribosomal DNA (rDNA) genes are rapidly transcribed by RNA polymerase I (pol I) molecules. Recent advances in our understanding of the pol I transcription system have indicated that regulation of ribosomal RNA (rRNA) sy...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1999-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200004 |
| _version_ | 1818583996856008704 |
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| author | Comai L. |
| author_facet | Comai L. |
| author_sort | Comai L. |
| collection | DOAJ |
| description | The nucleolus is the cellular site of ribosome biosynthesis. At this site, active ribosomal DNA (rDNA) genes are rapidly transcribed by RNA polymerase I (pol I) molecules. Recent advances in our understanding of the pol I transcription system have indicated that regulation of ribosomal RNA (rRNA) synthesis is a critical factor in cell growth. Importantly, the same signaling networks that control cell growth and proliferation and are deregulated in cancer appear to control pol I transcription. Therefore, the study of the biochemical basis for growth regulation of pol I transcription can provide basic information about the nuclear signaling network. Hopefully, this information may facilitate the search for drugs that can inhibit the growth of tumor cells by blocking pol I activation. In addition to its function in ribosome biogenesis, recent studies have revealed the prominent role of the nucleolus in cell senescence. These findings have stimulated a new wave of research on the functional relationship between the nucleolus and aging. The aim of this review is to provide an overview of some current topics in the area of nucleolus biology, and it has been written for a general readership. |
| first_indexed | 2024-12-16T08:14:10Z |
| format | Article |
| id | doaj.art-150bb4af23b74eddaf82f27991a214d6 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 0034-7310 |
| language | English |
| last_indexed | 2024-12-16T08:14:10Z |
| publishDate | 1999-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-150bb4af23b74eddaf82f27991a214d62022-12-21T22:38:18ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73101999-01-01321214731478The nucleolus: a paradigm for cell proliferation and agingComai L.The nucleolus is the cellular site of ribosome biosynthesis. At this site, active ribosomal DNA (rDNA) genes are rapidly transcribed by RNA polymerase I (pol I) molecules. Recent advances in our understanding of the pol I transcription system have indicated that regulation of ribosomal RNA (rRNA) synthesis is a critical factor in cell growth. Importantly, the same signaling networks that control cell growth and proliferation and are deregulated in cancer appear to control pol I transcription. Therefore, the study of the biochemical basis for growth regulation of pol I transcription can provide basic information about the nuclear signaling network. Hopefully, this information may facilitate the search for drugs that can inhibit the growth of tumor cells by blocking pol I activation. In addition to its function in ribosome biogenesis, recent studies have revealed the prominent role of the nucleolus in cell senescence. These findings have stimulated a new wave of research on the functional relationship between the nucleolus and aging. The aim of this review is to provide an overview of some current topics in the area of nucleolus biology, and it has been written for a general readership.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200004nucleolusRNA pol IagingtranscriptionWerner syndrome |
| spellingShingle | Comai L. The nucleolus: a paradigm for cell proliferation and aging Brazilian Journal of Medical and Biological Research nucleolus RNA pol I aging transcription Werner syndrome |
| title | The nucleolus: a paradigm for cell proliferation and aging |
| title_full | The nucleolus: a paradigm for cell proliferation and aging |
| title_fullStr | The nucleolus: a paradigm for cell proliferation and aging |
| title_full_unstemmed | The nucleolus: a paradigm for cell proliferation and aging |
| title_short | The nucleolus: a paradigm for cell proliferation and aging |
| title_sort | nucleolus a paradigm for cell proliferation and aging |
| topic | nucleolus RNA pol I aging transcription Werner syndrome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200004 |
| work_keys_str_mv | AT comail thenucleolusaparadigmforcellproliferationandaging AT comail nucleolusaparadigmforcellproliferationandaging |