A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives
<p>Abstract</p> <p>The Israeli acute paralysis virus (IAPV) is a honeybee-infecting virus that was found to be associated with colony collapse disorder. The IAPV genome contains two genes encoding a structural and a nonstructural polyprotein. We applied a recently developed method...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-09-01
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| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/6/1/144 |
| _version_ | 1818392155938357248 |
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| author | Price Nicholas Sabath Niv Graur Dan |
| author_facet | Price Nicholas Sabath Niv Graur Dan |
| author_sort | Price Nicholas |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The Israeli acute paralysis virus (IAPV) is a honeybee-infecting virus that was found to be associated with colony collapse disorder. The IAPV genome contains two genes encoding a structural and a nonstructural polyprotein. We applied a recently developed method for the estimation of selection in overlapping genes to detect purifying selection and, hence, functionality. We provide evolutionary evidence for the existence of a functional overlapping gene, which is translated in the +1 reading frame of the structural polyprotein gene. Conserved orthologs of this putative gene, which we provisionally call <it>pog </it>(<it>p</it>redicted <it>o</it>verlapping <it>g</it>ene), were also found in the genomes of a monophyletic clade of dicistroviruses that includes IAPV, acute bee paralysis virus, Kashmir bee virus, and <it>Solenopsis invicta </it>(red imported fire ant) virus 1.</p> |
| first_indexed | 2024-12-14T05:24:56Z |
| format | Article |
| id | doaj.art-150c02d3c04a44b5b77b4bfcebb00c92 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-14T05:24:56Z |
| publishDate | 2009-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-150c02d3c04a44b5b77b4bfcebb00c922022-12-21T23:15:33ZengBMCVirology Journal1743-422X2009-09-016114410.1186/1743-422X-6-144A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relativesPrice NicholasSabath NivGraur Dan<p>Abstract</p> <p>The Israeli acute paralysis virus (IAPV) is a honeybee-infecting virus that was found to be associated with colony collapse disorder. The IAPV genome contains two genes encoding a structural and a nonstructural polyprotein. We applied a recently developed method for the estimation of selection in overlapping genes to detect purifying selection and, hence, functionality. We provide evolutionary evidence for the existence of a functional overlapping gene, which is translated in the +1 reading frame of the structural polyprotein gene. Conserved orthologs of this putative gene, which we provisionally call <it>pog </it>(<it>p</it>redicted <it>o</it>verlapping <it>g</it>ene), were also found in the genomes of a monophyletic clade of dicistroviruses that includes IAPV, acute bee paralysis virus, Kashmir bee virus, and <it>Solenopsis invicta </it>(red imported fire ant) virus 1.</p>http://www.virologyj.com/content/6/1/144 |
| spellingShingle | Price Nicholas Sabath Niv Graur Dan A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives Virology Journal |
| title | A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives |
| title_full | A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives |
| title_fullStr | A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives |
| title_full_unstemmed | A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives |
| title_short | A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives |
| title_sort | potentially novel overlapping gene in the genomes of israeli acute paralysis virus and its relatives |
| url | http://www.virologyj.com/content/6/1/144 |
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