Enhanced mucosal immune responses and reduced viral load in the respiratory tract of ferrets to intranasal lipid nanoparticle-based SARS-CoV-2 proteins and mRNA vaccines

Enhanced mucosal immune responses and reduced viral load in the respiratory tract of ferrets to intranasal lipid nanoparticle-based SARS-CoV-2 proteins and mRNA vaccines

Abstract Background Unlike the injectable vaccines, intranasal lipid nanoparticle (NP)-based adjuvanted vaccine is promising to protect against local infection and viral transmission. Infection of ferrets with SARS-CoV-2 results in typical respiratory disease and pathology akin to in humans, suggest...

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Bibliographic Details
Main Authors: Patricia A. Boley, Carolyn M. Lee, Jennifer Schrock, Kush Kumar Yadav, Veerupaxagouda Patil, Raksha Suresh, Songqing Lu, Maoqi Mark Feng, Juliette Hanson, Rudra Channappanavar, Scott P. Kenney, Gourapura J. Renukaradhya
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Nanobiotechnology
Subjects:
Lipid nanoparticles
Intranasal vaccination
Subunit antigens
mRNA
Ferrets
Online Access:https://doi.org/10.1186/s12951-023-01816-3

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