Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arrest translation.
Bibliographic Details
| Main Authors: |
Bertrand Beckert,
Elodie C. Leroy,
Shanmugapriya Sothiselvam,
Lars V. Bock,
Maxim S. Svetlov,
Michael Graf,
Stefan Arenz,
Maha Abdelshahid,
Britta Seip,
Helmut Grubmüller,
Alexander S. Mankin,
C. Axel Innis,
Nora Vázquez-Laslop,
Daniel N. Wilson |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-24674-9
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