Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arrest translation.
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24674-9 |
| _version_ | 1819195093475655680 |
|---|---|
| author | Bertrand Beckert Elodie C. Leroy Shanmugapriya Sothiselvam Lars V. Bock Maxim S. Svetlov Michael Graf Stefan Arenz Maha Abdelshahid Britta Seip Helmut Grubmüller Alexander S. Mankin C. Axel Innis Nora Vázquez-Laslop Daniel N. Wilson |
| author_facet | Bertrand Beckert Elodie C. Leroy Shanmugapriya Sothiselvam Lars V. Bock Maxim S. Svetlov Michael Graf Stefan Arenz Maha Abdelshahid Britta Seip Helmut Grubmüller Alexander S. Mankin C. Axel Innis Nora Vázquez-Laslop Daniel N. Wilson |
| author_sort | Bertrand Beckert |
| collection | DOAJ |
| description | Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arrest translation. |
| first_indexed | 2024-12-23T02:07:17Z |
| format | Article |
| id | doaj.art-15117e74a84f4129bf14254d7d049216 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:07:17Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-15117e74a84f4129bf14254d7d0492162022-12-21T18:03:51ZengNature PortfolioNature Communications2041-17232021-07-0112111510.1038/s41467-021-24674-9Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibioticsBertrand Beckert0Elodie C. Leroy1Shanmugapriya Sothiselvam2Lars V. Bock3Maxim S. Svetlov4Michael Graf5Stefan Arenz6Maha Abdelshahid7Britta Seip8Helmut Grubmüller9Alexander S. Mankin10C. Axel Innis11Nora Vázquez-Laslop12Daniel N. Wilson13Institute for Biochemistry and Molecular Biology, University of HamburgUniv. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et BiologieCenter for Biomolecular Sciences, University of Illinois at ChicagoTheoretical and Computational Biophysics Department, Max Planck Institute for Biophysical ChemistryCenter for Biomolecular Sciences, University of Illinois at ChicagoInstitute for Biochemistry and Molecular Biology, University of HamburgInstitute for Biochemistry and Molecular Biology, University of HamburgInstitute for Biochemistry and Molecular Biology, University of HamburgUniv. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et BiologieTheoretical and Computational Biophysics Department, Max Planck Institute for Biophysical ChemistryCenter for Biomolecular Sciences, University of Illinois at ChicagoUniv. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et BiologieCenter for Biomolecular Sciences, University of Illinois at ChicagoInstitute for Biochemistry and Molecular Biology, University of HamburgMacrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arrest translation.https://doi.org/10.1038/s41467-021-24674-9 |
| spellingShingle | Bertrand Beckert Elodie C. Leroy Shanmugapriya Sothiselvam Lars V. Bock Maxim S. Svetlov Michael Graf Stefan Arenz Maha Abdelshahid Britta Seip Helmut Grubmüller Alexander S. Mankin C. Axel Innis Nora Vázquez-Laslop Daniel N. Wilson Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics Nature Communications |
| title | Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics |
| title_full | Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics |
| title_fullStr | Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics |
| title_full_unstemmed | Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics |
| title_short | Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics |
| title_sort | structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics |
| url | https://doi.org/10.1038/s41467-021-24674-9 |
| work_keys_str_mv | AT bertrandbeckert structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT elodiecleroy structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT shanmugapriyasothiselvam structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT larsvbock structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT maximssvetlov structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT michaelgraf structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT stefanarenz structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT mahaabdelshahid structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT brittaseip structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT helmutgrubmuller structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT alexandersmankin structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT caxelinnis structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT noravazquezlaslop structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics AT danielnwilson structuralandmechanisticbasisfortranslationinhibitionbymacrolideandketolideantibiotics |