Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging
Aging disrupts white matter integrity, and so does continuous elevated blood pressure that accompanies hypertension (HTN). Yet, our understanding of the interrelationship between these factors is still limited. The study aimed at evaluating patterns of changes in diffusion parameters (as assessed by...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00035/full |
| _version_ | 1819229305377390592 |
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| author | Agnieszka Sabisz Patrycja Naumczyk Anna Marcinkowska Beata Graff Dariusz Gąsecki Anna Glińska Marta Witkowska Anna Jankowska Aleksandra Konarzewska Jerzy Kwela Krzysztof Jodzio Edyta Szurowska Krzysztof Narkiewicz |
| author_facet | Agnieszka Sabisz Patrycja Naumczyk Anna Marcinkowska Beata Graff Dariusz Gąsecki Anna Glińska Marta Witkowska Anna Jankowska Aleksandra Konarzewska Jerzy Kwela Krzysztof Jodzio Edyta Szurowska Krzysztof Narkiewicz |
| author_sort | Agnieszka Sabisz |
| collection | DOAJ |
| description | Aging disrupts white matter integrity, and so does continuous elevated blood pressure that accompanies hypertension (HTN). Yet, our understanding of the interrelationship between these factors is still limited. The study aimed at evaluating patterns of changes in diffusion parameters (as assessed by quantitative diffusion fiber tracking – qDTI) following both aging, and hypertension, as well as the nature of their linkage. 146 participants took part in the study: the control group (N = 61) and the patients with hypertension (N = 85), and were divided into three age subgroups (25–47, 48–56, 57–71 years). qDTI was used to calculate the values of fractional anisotropy, mean, radial and axial diffusivity in 20 main tracts of the brain. The effects of factors (aging and hypertension) on diffusion parameters of tracts were tested with a two-way ANOVA. In the right hemisphere there was no clear effect of the HTN, nor an interaction between the factors, though some age-related effects were observed. Contrary, in the left hemisphere both aging and hypertension contributed to the white matter decline, following a functional pattern. In the projection pathways and the fornix, HTN and aging played part independent of each other, whereas in association fibers and the corpus callosum if the hypertension effect was significant, an interaction was observed. HTN patients manifested faster decline of diffusion parameters but also reached a plateau earlier, with highest between-group differences noted in the middle-aged subgroup. Healthy and hypertensive participants have different brain aging patterns. The HTN is associated with acceleration of white matter integrity decline, observed mainly in association fibers of the left hemisphere. |
| first_indexed | 2024-12-23T11:11:04Z |
| format | Article |
| id | doaj.art-15151a9fb4fe43b1abe532e4a364245c |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-23T11:11:04Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-15151a9fb4fe43b1abe532e4a364245c2022-12-21T17:49:20ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-02-011110.3389/fnagi.2019.00035400334Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor ImagingAgnieszka Sabisz0Patrycja Naumczyk1Anna Marcinkowska2Beata Graff3Dariusz Gąsecki4Anna Glińska5Marta Witkowska6Anna Jankowska7Aleksandra Konarzewska8Jerzy Kwela9Krzysztof Jodzio10Edyta Szurowska11Krzysztof Narkiewicz12Second Department of Radiology, Medical University of Gdańsk, Gdańsk, PolandInstitute of Psychology, University of Gdańsk, Gdańsk, PolandSecond Department of Radiology, Medical University of Gdańsk, Gdańsk, PolandDepartment of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, PolandDepartment of Neurology of Adults, Medical University of Gdańsk, Gdańsk, PolandSecond Department of Radiology, Medical University of Gdańsk, Gdańsk, PolandInstitute of Psychology, University of Gdańsk, Gdańsk, PolandSecond Department of Radiology, Medical University of Gdańsk, Gdańsk, PolandSecond Department of Radiology, Medical University of Gdańsk, Gdańsk, PolandInstitute of Experimental Physics, University of Gdańsk, Gdańsk, PolandInstitute of Psychology, University of Gdańsk, Gdańsk, PolandSecond Department of Radiology, Medical University of Gdańsk, Gdańsk, PolandDepartment of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, PolandAging disrupts white matter integrity, and so does continuous elevated blood pressure that accompanies hypertension (HTN). Yet, our understanding of the interrelationship between these factors is still limited. The study aimed at evaluating patterns of changes in diffusion parameters (as assessed by quantitative diffusion fiber tracking – qDTI) following both aging, and hypertension, as well as the nature of their linkage. 146 participants took part in the study: the control group (N = 61) and the patients with hypertension (N = 85), and were divided into three age subgroups (25–47, 48–56, 57–71 years). qDTI was used to calculate the values of fractional anisotropy, mean, radial and axial diffusivity in 20 main tracts of the brain. The effects of factors (aging and hypertension) on diffusion parameters of tracts were tested with a two-way ANOVA. In the right hemisphere there was no clear effect of the HTN, nor an interaction between the factors, though some age-related effects were observed. Contrary, in the left hemisphere both aging and hypertension contributed to the white matter decline, following a functional pattern. In the projection pathways and the fornix, HTN and aging played part independent of each other, whereas in association fibers and the corpus callosum if the hypertension effect was significant, an interaction was observed. HTN patients manifested faster decline of diffusion parameters but also reached a plateau earlier, with highest between-group differences noted in the middle-aged subgroup. Healthy and hypertensive participants have different brain aging patterns. The HTN is associated with acceleration of white matter integrity decline, observed mainly in association fibers of the left hemisphere.https://www.frontiersin.org/article/10.3389/fnagi.2019.00035/fullDTIaginghypertensionquantitative fiber trackingdiffusion tensor imaging |
| spellingShingle | Agnieszka Sabisz Patrycja Naumczyk Anna Marcinkowska Beata Graff Dariusz Gąsecki Anna Glińska Marta Witkowska Anna Jankowska Aleksandra Konarzewska Jerzy Kwela Krzysztof Jodzio Edyta Szurowska Krzysztof Narkiewicz Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging Frontiers in Aging Neuroscience DTI aging hypertension quantitative fiber tracking diffusion tensor imaging |
| title | Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging |
| title_full | Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging |
| title_fullStr | Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging |
| title_full_unstemmed | Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging |
| title_short | Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging |
| title_sort | aging and hypertension independent or intertwined white matter impairing factors insights from the quantitative diffusion tensor imaging |
| topic | DTI aging hypertension quantitative fiber tracking diffusion tensor imaging |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00035/full |
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