Literature Review of Cervical Regeneration after Loop Electrosurgical Excision Procedure, and Study Project (CeVaLEP) Proposal
Objective: To compile existing knowledge on the level of cervical regeneration (detected by ultrasound) after loop electrosurgical excision procedure (LEEP) and to suggest research protocol for further studies. Methods: We conducted a literature search of Medline, Web of Science, Scopus, and Cochran...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/8/2096 |
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| author | Laura Lūse Anda Ķīvīte Urtāne Ija Lisovaja Irina Jermakova Gilbert G. G. Donders Natālija Vedmedovska |
| author_facet | Laura Lūse Anda Ķīvīte Urtāne Ija Lisovaja Irina Jermakova Gilbert G. G. Donders Natālija Vedmedovska |
| author_sort | Laura Lūse |
| collection | DOAJ |
| description | Objective: To compile existing knowledge on the level of cervical regeneration (detected by ultrasound) after loop electrosurgical excision procedure (LEEP) and to suggest research protocol for further studies. Methods: We conducted a literature search of Medline, Web of Science, Scopus, and Cochrane databases using the keywords “cervix” and “regeneration” without year restrictions. Our eligibility criteria included studies that analysed cervical volume and length regeneration using ultrasound. A literature review was conducted following PRISMA guidelines and registered in PROSPERO (reg. no. CRD42021264062). Information about the studies was extracted from each analysed study on an Excel datasheet and the average regeneration with standard deviation was calculated. All included studies’ possible biases were assessed by the National Institutes of Health’s (NIH) quality assessment tool. Results: The literature search identified 802 papers and four trials (<i>n</i> = 309) that met our criteria. They investigated cervical length and volume regeneration after LEEP using ultrasound, concluding that there is a profound regeneration deficit. Average cervical length regeneration after 6 months was 83.4% (±10.8%) and volume regeneration was 87.4% (±6.1%). All analysed studies had their biases; therefore, based on the conducted studies’ protocols, we present a CeVaLEP research protocol to guide high-quality studies. Conclusion: After LEEP, there is a cervical regeneration deficit. There is a lack of high-quality studies that assess cervical volume regeneration and its relation to obstetrical outcomes. There is a gap in the field and more research is needed to define the prenatal risks related to cervical regeneration. |
| first_indexed | 2024-03-09T10:32:43Z |
| format | Article |
| id | doaj.art-151553850dc2417289d1587de2bc0113 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T10:32:43Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-151553850dc2417289d1587de2bc01132023-12-01T21:06:28ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01118209610.3390/jcm11082096Literature Review of Cervical Regeneration after Loop Electrosurgical Excision Procedure, and Study Project (CeVaLEP) ProposalLaura Lūse0Anda Ķīvīte Urtāne1Ija Lisovaja2Irina Jermakova3Gilbert G. G. Donders4Natālija Vedmedovska5Faculty of Residency, Rīga Stradiņš University, LV-1007 Riga, LatviaDepartment of Public Health and Epidemiology, Rīga Stradiņš University, LV-1007 Riga, LatviaFaculty of Residency, Rīga Stradiņš University, LV-1007 Riga, LatviaGynecology Department, Riga Eastern Clinical University Hospital, LV-1079 Riga, LatviaDepartment OB/Gyn, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Obstetrics and Gynecology, Rīga Stradiņš University, LV-1007 Riga, LatviaObjective: To compile existing knowledge on the level of cervical regeneration (detected by ultrasound) after loop electrosurgical excision procedure (LEEP) and to suggest research protocol for further studies. Methods: We conducted a literature search of Medline, Web of Science, Scopus, and Cochrane databases using the keywords “cervix” and “regeneration” without year restrictions. Our eligibility criteria included studies that analysed cervical volume and length regeneration using ultrasound. A literature review was conducted following PRISMA guidelines and registered in PROSPERO (reg. no. CRD42021264062). Information about the studies was extracted from each analysed study on an Excel datasheet and the average regeneration with standard deviation was calculated. All included studies’ possible biases were assessed by the National Institutes of Health’s (NIH) quality assessment tool. Results: The literature search identified 802 papers and four trials (<i>n</i> = 309) that met our criteria. They investigated cervical length and volume regeneration after LEEP using ultrasound, concluding that there is a profound regeneration deficit. Average cervical length regeneration after 6 months was 83.4% (±10.8%) and volume regeneration was 87.4% (±6.1%). All analysed studies had their biases; therefore, based on the conducted studies’ protocols, we present a CeVaLEP research protocol to guide high-quality studies. Conclusion: After LEEP, there is a cervical regeneration deficit. There is a lack of high-quality studies that assess cervical volume regeneration and its relation to obstetrical outcomes. There is a gap in the field and more research is needed to define the prenatal risks related to cervical regeneration.https://www.mdpi.com/2077-0383/11/8/2096cervical intraepithelial neoplasiapreterm deliverycervix uteriHPVmicrobiotacone resection |
| spellingShingle | Laura Lūse Anda Ķīvīte Urtāne Ija Lisovaja Irina Jermakova Gilbert G. G. Donders Natālija Vedmedovska Literature Review of Cervical Regeneration after Loop Electrosurgical Excision Procedure, and Study Project (CeVaLEP) Proposal Journal of Clinical Medicine cervical intraepithelial neoplasia preterm delivery cervix uteri HPV microbiota cone resection |
| title | Literature Review of Cervical Regeneration after Loop Electrosurgical Excision Procedure, and Study Project (CeVaLEP) Proposal |
| title_full | Literature Review of Cervical Regeneration after Loop Electrosurgical Excision Procedure, and Study Project (CeVaLEP) Proposal |
| title_fullStr | Literature Review of Cervical Regeneration after Loop Electrosurgical Excision Procedure, and Study Project (CeVaLEP) Proposal |
| title_full_unstemmed | Literature Review of Cervical Regeneration after Loop Electrosurgical Excision Procedure, and Study Project (CeVaLEP) Proposal |
| title_short | Literature Review of Cervical Regeneration after Loop Electrosurgical Excision Procedure, and Study Project (CeVaLEP) Proposal |
| title_sort | literature review of cervical regeneration after loop electrosurgical excision procedure and study project cevalep proposal |
| topic | cervical intraepithelial neoplasia preterm delivery cervix uteri HPV microbiota cone resection |
| url | https://www.mdpi.com/2077-0383/11/8/2096 |
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