Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells
<p>Despite the introduction of many novel therapeutics in clinical practice, metastatic renal cell carcinoma (RCC) remains a treatment-re-sistant cancer. As red and processed meat are considered risk factors for RCC, and a vegetable-rich diet is thought to reduce this risk, research into plant...
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| Format: | Article |
| Language: | English |
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Codon Publications
2017-03-01
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| Series: | Journal of Kidney Cancer and VHL |
| Subjects: | |
| Online Access: | http://jkcvhl.com/index.php/jkcvhl/article/view/64 |
| _version_ | 1819072259144286208 |
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| author | Parth Thakor Wenzhe Song Ramalingam B. Subramanian Vasudev R. Thakkar David A. Vesey Glenda C Gobe |
| author_facet | Parth Thakor Wenzhe Song Ramalingam B. Subramanian Vasudev R. Thakkar David A. Vesey Glenda C Gobe |
| author_sort | Parth Thakor |
| collection | DOAJ |
| description | <p>Despite the introduction of many novel therapeutics in clinical practice, metastatic renal cell carcinoma (RCC) remains a treatment-re-sistant cancer. As red and processed meat are considered risk factors for RCC, and a vegetable-rich diet is thought to reduce this risk, research into plant-based therapeutics may provide valuable complementary or alternative therapeutics for the management of RCC. Herein, we present the antiproliferative and antiangiogenic effects of maslinic acid, which occurs naturally in edible plants, particularly in olive fruits, and also in a variety of medicinal plants. Human RCC cell lines (ACHN, Caki-1, and SN12K1), endothelial cells (human umbilical vein endothelial cell line [HUVEC]), and primary cultures of kidney proximal tubular epithelial cells (PTEC) were treated with maslinic acid. Maslinic acid was relatively less toxic to PTEC when compared with RCC under similar experimental conditions. In RCC cell lines, maslinic acid induced a significant reduction in proliferation, proliferating cell nuclear antigen, and colony formation. In HUVEC, maslinic acid induced a significant reduction in capillary tube formation in vitro and vascular endothelial growth factor. This study provides a rationale for incorporating a maslinic acid–rich diet either to reduce the risk of developing kidney cancer or as an adjunct to existing antiangiogenic therapy to improve efficacy.</p> |
| first_indexed | 2024-12-21T17:34:53Z |
| format | Article |
| id | doaj.art-1515a7247eab4e87998fcf8f8fe6e93e |
| institution | Directory Open Access Journal |
| issn | 2203-5826 |
| language | English |
| last_indexed | 2024-12-21T17:34:53Z |
| publishDate | 2017-03-01 |
| publisher | Codon Publications |
| record_format | Article |
| series | Journal of Kidney Cancer and VHL |
| spelling | doaj.art-1515a7247eab4e87998fcf8f8fe6e93e2022-12-21T18:55:48ZengCodon PublicationsJournal of Kidney Cancer and VHL2203-58262017-03-0141162410.15586/jkcvhl.2017.6445Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cellsParth Thakor0Wenzhe Song1Ramalingam B. Subramanian2Vasudev R. Thakkar3David A. Vesey4Glenda C Gobe5B. R. D. School of Biosciences, Sardar Patel University, Vallabhvidyanagar, GujaratDepartment of General Surgery, Affiliated Hospital to Xuzhou Medical University, XuzhouB. R. D. School of Biosciences, Sardar Patel University, Vallabhvidyanagar, GujaratB. R. D. School of Biosciences, Sardar Patel University, Vallabhvidyanagar, GujaratDepartment of Renal Medicine, The University of Queensland at Princess Alexandra Hospital, Brisbane, QueenslandCentre for Kidney Disease Research, School of Medicine, Translational Research Institute, The University of Queensland, Brisbane, Queensland 4102<p>Despite the introduction of many novel therapeutics in clinical practice, metastatic renal cell carcinoma (RCC) remains a treatment-re-sistant cancer. As red and processed meat are considered risk factors for RCC, and a vegetable-rich diet is thought to reduce this risk, research into plant-based therapeutics may provide valuable complementary or alternative therapeutics for the management of RCC. Herein, we present the antiproliferative and antiangiogenic effects of maslinic acid, which occurs naturally in edible plants, particularly in olive fruits, and also in a variety of medicinal plants. Human RCC cell lines (ACHN, Caki-1, and SN12K1), endothelial cells (human umbilical vein endothelial cell line [HUVEC]), and primary cultures of kidney proximal tubular epithelial cells (PTEC) were treated with maslinic acid. Maslinic acid was relatively less toxic to PTEC when compared with RCC under similar experimental conditions. In RCC cell lines, maslinic acid induced a significant reduction in proliferation, proliferating cell nuclear antigen, and colony formation. In HUVEC, maslinic acid induced a significant reduction in capillary tube formation in vitro and vascular endothelial growth factor. This study provides a rationale for incorporating a maslinic acid–rich diet either to reduce the risk of developing kidney cancer or as an adjunct to existing antiangiogenic therapy to improve efficacy.</p>http://jkcvhl.com/index.php/jkcvhl/article/view/64angiogenesismaslinic acidproliferating cell nuclear antigenrenal cell carcinomavascular endothelial growth factor |
| spellingShingle | Parth Thakor Wenzhe Song Ramalingam B. Subramanian Vasudev R. Thakkar David A. Vesey Glenda C Gobe Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells Journal of Kidney Cancer and VHL angiogenesis maslinic acid proliferating cell nuclear antigen renal cell carcinoma vascular endothelial growth factor |
| title | Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells |
| title_full | Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells |
| title_fullStr | Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells |
| title_full_unstemmed | Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells |
| title_short | Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells |
| title_sort | maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells |
| topic | angiogenesis maslinic acid proliferating cell nuclear antigen renal cell carcinoma vascular endothelial growth factor |
| url | http://jkcvhl.com/index.php/jkcvhl/article/view/64 |
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