Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study
IntroductionVitamin D has been known to be associated with asthma, particularly in children, while the evidence among adults is limited and inconclusive. This study aimed to investigate the association between serum, vitamin D concentrations, and the incidence of adult-onset asthma and also the modi...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1222499/full |
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| author | Qinyu Chang Qinyu Chang Qinyu Chang Yiqun Zhu Yiqun Zhu Yiqun Zhu Guowei Zhou Huaying Liang Huaying Liang Huaying Liang Dianwu Li Dianwu Li Dianwu Li Jun Cheng Jun Cheng Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Yan Zhang Yan Zhang Yan Zhang Yan Zhang |
| author_facet | Qinyu Chang Qinyu Chang Qinyu Chang Yiqun Zhu Yiqun Zhu Yiqun Zhu Guowei Zhou Huaying Liang Huaying Liang Huaying Liang Dianwu Li Dianwu Li Dianwu Li Jun Cheng Jun Cheng Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Yan Zhang Yan Zhang Yan Zhang Yan Zhang |
| author_sort | Qinyu Chang |
| collection | DOAJ |
| description | IntroductionVitamin D has been known to be associated with asthma, particularly in children, while the evidence among adults is limited and inconclusive. This study aimed to investigate the association between serum, vitamin D concentrations, and the incidence of adult-onset asthma and also the modified effect caused by sleep patterns and genetic risks.MethodsA prospective cohort study with 307,872 participants aged between 37 and 73 years was conducted based on the UK Biobank, with a median follow-up of 12 years. The Cox proportional hazard model was applied to evaluate the association between vitamin D status and incident adult-onset asthma, and the modified effect was investigated by conducting stratified analysis according to sleep pattern score and genetic risk score, and subgroup analyses were performed by sex, age, BMI, and smoking status as well.ResultsIndividuals with optimal vitamin D concentration were associated with 11.1% reduced risk of incident asthma compared to those participants with deficient vitamin D (HR = 0.889; 95% CI: 0.820–0.964; p = 0.005). Moreover, stratification analysis demonstrated that the protective effect of vitamin D on asthma risk was modified by sleep patterns or genetic susceptibility, with the strongest protective effect being observed in the subpopulation with a moderate sleep pattern (HR = 0.883; 95% CI: 0.797–0.977; p = 0.016) and a moderate genetic risk (HR = 0.817; 95% CI: 0.711–0.938; p = 0.004). In subgroup analyses, the protective effect of optimal vitamin D levels was only significant among men, individuals younger than 60 years of age, overweight individuals, and current or previous smokers.ConclusionIncreased serum vitamin D levels were associated with a lower risk of incident adult-onset asthma, and this association was modified by sleep patterns and genetic predisposition to some extent. |
| first_indexed | 2024-03-13T02:14:40Z |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T02:14:40Z |
| publishDate | 2023-06-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-1516705911e348f3adf554252e624dc02023-06-30T17:42:23ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-06-011010.3389/fnut.2023.12224991222499Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort studyQinyu Chang0Qinyu Chang1Qinyu Chang2Yiqun Zhu3Yiqun Zhu4Yiqun Zhu5Guowei Zhou6Huaying Liang7Huaying Liang8Huaying Liang9Dianwu Li10Dianwu Li11Dianwu Li12Jun Cheng13Jun Cheng14Pinhua Pan15Pinhua Pan16Pinhua Pan17Pinhua Pan18Yan Zhang19Yan Zhang20Yan Zhang21Yan Zhang22Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, Hunan, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, Hunan, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, Hunan, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, Hunan, ChinaDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaIntroductionVitamin D has been known to be associated with asthma, particularly in children, while the evidence among adults is limited and inconclusive. This study aimed to investigate the association between serum, vitamin D concentrations, and the incidence of adult-onset asthma and also the modified effect caused by sleep patterns and genetic risks.MethodsA prospective cohort study with 307,872 participants aged between 37 and 73 years was conducted based on the UK Biobank, with a median follow-up of 12 years. The Cox proportional hazard model was applied to evaluate the association between vitamin D status and incident adult-onset asthma, and the modified effect was investigated by conducting stratified analysis according to sleep pattern score and genetic risk score, and subgroup analyses were performed by sex, age, BMI, and smoking status as well.ResultsIndividuals with optimal vitamin D concentration were associated with 11.1% reduced risk of incident asthma compared to those participants with deficient vitamin D (HR = 0.889; 95% CI: 0.820–0.964; p = 0.005). Moreover, stratification analysis demonstrated that the protective effect of vitamin D on asthma risk was modified by sleep patterns or genetic susceptibility, with the strongest protective effect being observed in the subpopulation with a moderate sleep pattern (HR = 0.883; 95% CI: 0.797–0.977; p = 0.016) and a moderate genetic risk (HR = 0.817; 95% CI: 0.711–0.938; p = 0.004). In subgroup analyses, the protective effect of optimal vitamin D levels was only significant among men, individuals younger than 60 years of age, overweight individuals, and current or previous smokers.ConclusionIncreased serum vitamin D levels were associated with a lower risk of incident adult-onset asthma, and this association was modified by sleep patterns and genetic predisposition to some extent.https://www.frontiersin.org/articles/10.3389/fnut.2023.1222499/fullVitamin Dsleep behaviorsgenetic susceptibilityasthmaUK biobank |
| spellingShingle | Qinyu Chang Qinyu Chang Qinyu Chang Yiqun Zhu Yiqun Zhu Yiqun Zhu Guowei Zhou Huaying Liang Huaying Liang Huaying Liang Dianwu Li Dianwu Li Dianwu Li Jun Cheng Jun Cheng Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Yan Zhang Yan Zhang Yan Zhang Yan Zhang Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study Frontiers in Nutrition Vitamin D sleep behaviors genetic susceptibility asthma UK biobank |
| title | Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study |
| title_full | Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study |
| title_fullStr | Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study |
| title_full_unstemmed | Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study |
| title_short | Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study |
| title_sort | vitamin d status sleep patterns genetic susceptibility and the risk of incident adult onset asthma a large prospective cohort study |
| topic | Vitamin D sleep behaviors genetic susceptibility asthma UK biobank |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1222499/full |
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