The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy
OBJECTIVE: There are cases where ultrasonographic evaluation is inadequate in determining first-trimester healthy pregnancy. In these cases, both the patient and the clinician are involved in a worrying expectation. The single serum progesterone measurement was tried to predict pregnancy prognosis i...
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| Format: | Article |
| Language: | English |
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Medical Network
2020-03-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/942 |
| _version_ | 1797911359284838400 |
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| author | Mehmet Nafi Sakar Deniz Balsak Sureyya Demir Mehmet Sukru Budak Ali Emre Tahaoglu Sinan Emre Gungor Emrullah Akay Bulent Demir |
| author_facet | Mehmet Nafi Sakar Deniz Balsak Sureyya Demir Mehmet Sukru Budak Ali Emre Tahaoglu Sinan Emre Gungor Emrullah Akay Bulent Demir |
| author_sort | Mehmet Nafi Sakar |
| collection | DOAJ |
| description | OBJECTIVE: There are cases where ultrasonographic evaluation is inadequate in determining first-trimester healthy pregnancy. In these cases, both the patient and the clinician are involved in a worrying expectation. The single serum progesterone measurement was tried to predict pregnancy prognosis in short time period. This study evaluated the predictive value of a single serum progesterone measurement in first-trimester pregnancy loss.
STUDY DESIGN: A prospective case-control study was conducted between July 2013 and July 2014 in Tertiary Hospital. The study compared 106 patients with threatened abortion (vaginal bleeding or spotting) before 13 weeks of gestation with 110 healthy control pregnancies. Samples of serum progesterone were obtained on the day each patient was admitted to the hospital. A Beckman-Coulter macro-Enzyme-linked immunoassay (ELISA) system was used to measure serum levels of progesterone (Beckman-Coulter, Ireland).
RESULTS: Progesterone levels were measured when the patients first visited the hospital and they were followed until the end of the first trimester. Progesterone levels differed significantly (p=0.013) between the two groups. The spontaneous abortion rate was significantly (p=0.044) higher in the case group. Progesterone levels differed significantly (p=0.001) between ongoing pregnancy and spontaneous abortion groups. Using a cut-off level of 10.7 ng/mL, the sensitivity, specificity, and positive and negative predictive values were 92.1%, 44%, 92.6%, and 42.3%, respectively, for viable pregnancies.
CONCLUSION: A single measurement of progesterone levels in serum can predict the prognosis of a viable first-trimester pregnancy, while it is less effective for identifying non-viable pregnancies. |
| first_indexed | 2024-04-10T11:39:21Z |
| format | Article |
| id | doaj.art-1518d36c7d694564a56e2c777cad0dd0 |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T11:39:21Z |
| publishDate | 2020-03-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-1518d36c7d694564a56e2c777cad0dd02023-02-15T16:17:36ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512020-03-012611510.21613/GORM.2019.942708The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester PregnancyMehmet Nafi Sakar0Deniz Balsak1Sureyya Demir2Mehmet Sukru Budak3Ali Emre Tahaoglu4Sinan Emre Gungor5Emrullah Akay6Bulent Demir7Memorial Diyarbakir HospitalSchool of Medicine, Halic UniversitySchool of Medicine, Dokuz Eylul UniversityDiyarbakir Gazi Yasargil Education and Research Hospital, Health Sciences UniversityDiyarbakir Gazi Yasargil Education and Research Hospital, Health Sciences UniversitySuleymaniye Education and Research Hospital, Health Sciences UniversitySuleymaniye Education and Research Hospital, Health Sciences UniversitySchool of Medicine, Onsekiz Mart UniversityOBJECTIVE: There are cases where ultrasonographic evaluation is inadequate in determining first-trimester healthy pregnancy. In these cases, both the patient and the clinician are involved in a worrying expectation. The single serum progesterone measurement was tried to predict pregnancy prognosis in short time period. This study evaluated the predictive value of a single serum progesterone measurement in first-trimester pregnancy loss. STUDY DESIGN: A prospective case-control study was conducted between July 2013 and July 2014 in Tertiary Hospital. The study compared 106 patients with threatened abortion (vaginal bleeding or spotting) before 13 weeks of gestation with 110 healthy control pregnancies. Samples of serum progesterone were obtained on the day each patient was admitted to the hospital. A Beckman-Coulter macro-Enzyme-linked immunoassay (ELISA) system was used to measure serum levels of progesterone (Beckman-Coulter, Ireland). RESULTS: Progesterone levels were measured when the patients first visited the hospital and they were followed until the end of the first trimester. Progesterone levels differed significantly (p=0.013) between the two groups. The spontaneous abortion rate was significantly (p=0.044) higher in the case group. Progesterone levels differed significantly (p=0.001) between ongoing pregnancy and spontaneous abortion groups. Using a cut-off level of 10.7 ng/mL, the sensitivity, specificity, and positive and negative predictive values were 92.1%, 44%, 92.6%, and 42.3%, respectively, for viable pregnancies. CONCLUSION: A single measurement of progesterone levels in serum can predict the prognosis of a viable first-trimester pregnancy, while it is less effective for identifying non-viable pregnancies.http://gorm.com.tr/index.php/GORM/article/view/942first trimester, prognosis, serum progesterone |
| spellingShingle | Mehmet Nafi Sakar Deniz Balsak Sureyya Demir Mehmet Sukru Budak Ali Emre Tahaoglu Sinan Emre Gungor Emrullah Akay Bulent Demir The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy Gynecology Obstetrics & Reproductive Medicine first trimester, prognosis, serum progesterone |
| title | The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy |
| title_full | The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy |
| title_fullStr | The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy |
| title_full_unstemmed | The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy |
| title_short | The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy |
| title_sort | ability of a single serum progesterone measurement to predict the prognosis of first trimester pregnancy |
| topic | first trimester, prognosis, serum progesterone |
| url | http://gorm.com.tr/index.php/GORM/article/view/942 |
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