CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Abstract. The aim of present study was to evaluate clinical and prognostic value of various inflammationmarkers in patients after Q-wave myocardial infarction (MI). Results: Among multiple inflammation factors studied, only TNFα, IL-12 and CRP levels proved to be...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/471 |
| _version_ | 1797198068149387264 |
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| author | M. V. Zykov O. L. Barbarash V. V. Kashtalap A. V. Veremeev L. S. Barbarash |
| author_facet | M. V. Zykov O. L. Barbarash V. V. Kashtalap A. V. Veremeev L. S. Barbarash |
| author_sort | M. V. Zykov |
| collection | DOAJ |
| description | Abstract. The aim of present study was to evaluate clinical and prognostic value of various inflammationmarkers in patients after Q-wave myocardial infarction (MI). Results: Among multiple inflammation factors studied, only TNFα, IL-12 and CRP levels proved to be significantly increased in the patients with multi-vesselcoronary artery disease, as compared to the patients with single coronary lesions. A positive correlation was revealed between the levels of IL-12 and IL-6 inflammation markers, and severity of atherosclerotic lesions of non-coronary arteries (brachiocephalic vessels, or lower limb arteries). Regression analysis, using an iterative approach, showed that patients’ age of ≥ 53 years and IL-12 levels ≥ 87.1 pg/ml are of highest predictive value, when detecting clinically significant coronary lesions. Meanwhile, the age of ≥ 65 years and IL- 12 levels exceeding 108.8 pg/ml allow of detecting haemodynamically significant non-coronary lesions. Acute heart failure according to Killip class II and more, and IL-12 levels over 90 pg/ml have been verified as independent variables for risk stratification of any cardiovascular event within a year after MI. Hence, among all studied inflammatory indexes, IL-12 possesses the greatest diagnostic value in defining patients at a high risk for severe coronary and multifocal atherosclerosis and subsequent complications. (Med. Immunol., 2011, vol. 13, N 2-3, pp 219-226) |
| first_indexed | 2024-03-08T05:50:22Z |
| format | Article |
| id | doaj.art-1519a2b5f04345f3a7deb12a78063bf1 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:59Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-1519a2b5f04345f3a7deb12a78063bf12024-04-22T13:07:37ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01132-321922610.15789/1563-0625-2011-2-3-219-226468CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTIONM. V. Zykov0O. L. Barbarash1V. V. Kashtalap2A. V. Veremeev3L. S. Barbarash4Учреждение РАМН Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. КемеровоГосударственное образовательное учреждение высшего профессионального образования Кемеровская государственная медицинская академия Росздрава, г. КемеровоУчреждение РАМН Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. КемеровоУчреждение РАМН Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. КемеровоУчреждение РАМН Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. КемеровоAbstract. The aim of present study was to evaluate clinical and prognostic value of various inflammationmarkers in patients after Q-wave myocardial infarction (MI). Results: Among multiple inflammation factors studied, only TNFα, IL-12 and CRP levels proved to be significantly increased in the patients with multi-vesselcoronary artery disease, as compared to the patients with single coronary lesions. A positive correlation was revealed between the levels of IL-12 and IL-6 inflammation markers, and severity of atherosclerotic lesions of non-coronary arteries (brachiocephalic vessels, or lower limb arteries). Regression analysis, using an iterative approach, showed that patients’ age of ≥ 53 years and IL-12 levels ≥ 87.1 pg/ml are of highest predictive value, when detecting clinically significant coronary lesions. Meanwhile, the age of ≥ 65 years and IL- 12 levels exceeding 108.8 pg/ml allow of detecting haemodynamically significant non-coronary lesions. Acute heart failure according to Killip class II and more, and IL-12 levels over 90 pg/ml have been verified as independent variables for risk stratification of any cardiovascular event within a year after MI. Hence, among all studied inflammatory indexes, IL-12 possesses the greatest diagnostic value in defining patients at a high risk for severe coronary and multifocal atherosclerosis and subsequent complications. (Med. Immunol., 2011, vol. 13, N 2-3, pp 219-226)https://www.mimmun.ru/mimmun/article/view/471coronary vesselsatherosclerosisinflammation markersil-12diagnostic significance |
| spellingShingle | M. V. Zykov O. L. Barbarash V. V. Kashtalap A. V. Veremeev L. S. Barbarash CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Медицинская иммунология coronary vessels atherosclerosis inflammation markers il-12 diagnostic significance |
| title | CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_full | CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_fullStr | CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_full_unstemmed | CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_short | CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_sort | clinical and prognostic value of interleukin 12 in patients with acute myocardial infarction |
| topic | coronary vessels atherosclerosis inflammation markers il-12 diagnostic significance |
| url | https://www.mimmun.ru/mimmun/article/view/471 |
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