Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population
<p>Abstract</p> <p>Background</p> <p>This study was designed to investigate an association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of lung cancer in a Korean population.</p> <p>Methods</p> <p>We conduct...
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| Format: | Article |
| Language: | English |
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BMC
2011-02-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/12/28 |
| _version_ | 1818777164108005376 |
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| author | Yun Woo-Jun Choi Jin-Su Kweon Sun-Seog Piao Jin-Mei Song Hye-Rim Kim Hee Shin Min-Ho Cui Lian-Hua Kim Young-Chul Oh In-Jae Kim Kyu-Sik |
| author_facet | Yun Woo-Jun Choi Jin-Su Kweon Sun-Seog Piao Jin-Mei Song Hye-Rim Kim Hee Shin Min-Ho Cui Lian-Hua Kim Young-Chul Oh In-Jae Kim Kyu-Sik |
| author_sort | Yun Woo-Jun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This study was designed to investigate an association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of lung cancer in a Korean population.</p> <p>Methods</p> <p>We conducted a large-scale, case-control study involving 3938 patients with newly diagnosed lung cancer and 1700 healthy controls. Genotyping was performed with peripheral blood DNA for MTHFR C677T polymorphisms. Statistical significance was estimated by logistic regression analysis.</p> <p>Results</p> <p>The MTHFR C677T frequencies of CC, CT, and TT genotypes were 34.5%, 48.5%, and 17% among lung cancer patients, and 31.8%, 50.7%, and 17.5% in the controls, respectively. The MTHFR 677CT and TT genotype showed a weak protection against lung cancer compared with the homozygous CC genotype, although the results did not reach statistical significance. The age- and gender-adjusted odds ratio (OR) of overall lung cancer was 0.90 (95% confidence interval (CI), 0.77-1.04) for MTHFR 677 CT and 0.88 (95% CI, 0.71-1.07) for MTHFR 677TT. However, after stratification analysis by histological type, the MTHFR 677CT genotype showed a significantly decreased risk for squamous cell carcinoma (age- and gender-adjusted OR, 0.78; 95% CI, 0.64-0.96). The combination of 677 TT homozygous with 677 CT heterozygous also appeared to have a protection effect on the risk of squamous cell carcinoma. We observed no significant interaction between the MTHFR C677T polymorphism and age and gender or smoking habit.</p> <p>Conclusions</p> <p>This is the first reported study focusing on the association between MTHFR C677T polymorphisms and the risk of lung cancer in a Korean population. The T allele was found to provide a weak protective association with lung squamous cell carcinoma.</p> |
| first_indexed | 2024-12-18T11:24:28Z |
| format | Article |
| id | doaj.art-151a17b05a164b2195cda7d1a349c31b |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-18T11:24:28Z |
| publishDate | 2011-02-01 |
| publisher | BMC |
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| series | BMC Medical Genetics |
| spelling | doaj.art-151a17b05a164b2195cda7d1a349c31b2022-12-21T21:09:45ZengBMCBMC Medical Genetics1471-23502011-02-011212810.1186/1471-2350-12-28Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean populationYun Woo-JunChoi Jin-SuKweon Sun-SeogPiao Jin-MeiSong Hye-RimKim HeeShin Min-HoCui Lian-HuaKim Young-ChulOh In-JaeKim Kyu-Sik<p>Abstract</p> <p>Background</p> <p>This study was designed to investigate an association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of lung cancer in a Korean population.</p> <p>Methods</p> <p>We conducted a large-scale, case-control study involving 3938 patients with newly diagnosed lung cancer and 1700 healthy controls. Genotyping was performed with peripheral blood DNA for MTHFR C677T polymorphisms. Statistical significance was estimated by logistic regression analysis.</p> <p>Results</p> <p>The MTHFR C677T frequencies of CC, CT, and TT genotypes were 34.5%, 48.5%, and 17% among lung cancer patients, and 31.8%, 50.7%, and 17.5% in the controls, respectively. The MTHFR 677CT and TT genotype showed a weak protection against lung cancer compared with the homozygous CC genotype, although the results did not reach statistical significance. The age- and gender-adjusted odds ratio (OR) of overall lung cancer was 0.90 (95% confidence interval (CI), 0.77-1.04) for MTHFR 677 CT and 0.88 (95% CI, 0.71-1.07) for MTHFR 677TT. However, after stratification analysis by histological type, the MTHFR 677CT genotype showed a significantly decreased risk for squamous cell carcinoma (age- and gender-adjusted OR, 0.78; 95% CI, 0.64-0.96). The combination of 677 TT homozygous with 677 CT heterozygous also appeared to have a protection effect on the risk of squamous cell carcinoma. We observed no significant interaction between the MTHFR C677T polymorphism and age and gender or smoking habit.</p> <p>Conclusions</p> <p>This is the first reported study focusing on the association between MTHFR C677T polymorphisms and the risk of lung cancer in a Korean population. The T allele was found to provide a weak protective association with lung squamous cell carcinoma.</p>http://www.biomedcentral.com/1471-2350/12/28 |
| spellingShingle | Yun Woo-Jun Choi Jin-Su Kweon Sun-Seog Piao Jin-Mei Song Hye-Rim Kim Hee Shin Min-Ho Cui Lian-Hua Kim Young-Chul Oh In-Jae Kim Kyu-Sik Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population BMC Medical Genetics |
| title | Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population |
| title_full | Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population |
| title_fullStr | Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population |
| title_full_unstemmed | Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population |
| title_short | Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population |
| title_sort | methylenetetrahydrofolate reductase c677t polymorphism in patients with lung cancer in a korean population |
| url | http://www.biomedcentral.com/1471-2350/12/28 |
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