The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans
Generating specific, robust protective responses to different bacteria is vital for animal survival. Here, we address the role of transforming growth factor β (TGF-β) member DBL-1 in regulating signature host defense responses in Caenorhabditis elegans to human opportunistic Gram-negative and Gram-p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2023-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/75831 |
| _version_ | 1797661828164091904 |
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| author | Bhoomi Madhu Mohammed Farhan Lakdawala Tina L Gumienny |
| author_facet | Bhoomi Madhu Mohammed Farhan Lakdawala Tina L Gumienny |
| author_sort | Bhoomi Madhu |
| collection | DOAJ |
| description | Generating specific, robust protective responses to different bacteria is vital for animal survival. Here, we address the role of transforming growth factor β (TGF-β) member DBL-1 in regulating signature host defense responses in Caenorhabditis elegans to human opportunistic Gram-negative and Gram-positive pathogens. Canonical DBL-1 signaling is required to suppress avoidance behavior in response to Gram-negative, but not Gram-positive bacteria. We propose that in the absence of DBL-1, animals perceive some bacteria as more harmful. Animals activate DBL-1 pathway activity in response to Gram-negative bacteria and strongly repress it in response to select Gram-positive bacteria, demonstrating bacteria-responsive regulation of DBL-1 signaling. DBL-1 signaling differentially regulates expression of target innate immunity genes depending on the bacterial exposure. These findings highlight a central role for TGF-β in tailoring a suite of bacteria-specific host defenses. |
| first_indexed | 2024-03-11T18:50:23Z |
| format | Article |
| id | doaj.art-151a8960094a45dcbb5c81759dd2c212 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-11T18:50:23Z |
| publishDate | 2023-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-151a8960094a45dcbb5c81759dd2c2122023-10-11T12:06:35ZengeLife Sciences Publications LtdeLife2050-084X2023-09-011210.7554/eLife.75831The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegansBhoomi Madhu0https://orcid.org/0000-0002-8931-5345Mohammed Farhan Lakdawala1https://orcid.org/0000-0003-2271-2255Tina L Gumienny2https://orcid.org/0000-0002-3932-7815Department of Biology, Texas Woman’s University, Denton, United States; Perelman School of Medicine, University of Pennsylvania, Philadelphia, United StatesDepartment of Biology, Texas Woman’s University, Denton, United States; AbbVie (United States), Worcester, United StatesDepartment of Biology, Texas Woman’s University, Denton, United StatesGenerating specific, robust protective responses to different bacteria is vital for animal survival. Here, we address the role of transforming growth factor β (TGF-β) member DBL-1 in regulating signature host defense responses in Caenorhabditis elegans to human opportunistic Gram-negative and Gram-positive pathogens. Canonical DBL-1 signaling is required to suppress avoidance behavior in response to Gram-negative, but not Gram-positive bacteria. We propose that in the absence of DBL-1, animals perceive some bacteria as more harmful. Animals activate DBL-1 pathway activity in response to Gram-negative bacteria and strongly repress it in response to select Gram-positive bacteria, demonstrating bacteria-responsive regulation of DBL-1 signaling. DBL-1 signaling differentially regulates expression of target innate immunity genes depending on the bacterial exposure. These findings highlight a central role for TGF-β in tailoring a suite of bacteria-specific host defenses.https://elifesciences.org/articles/75831innate immunityhost responsedbl-1TGF-βC. elegansSmad |
| spellingShingle | Bhoomi Madhu Mohammed Farhan Lakdawala Tina L Gumienny The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans eLife innate immunity host response dbl-1 TGF-β C. elegans Smad |
| title | The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans |
| title_full | The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans |
| title_fullStr | The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans |
| title_full_unstemmed | The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans |
| title_short | The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans |
| title_sort | dbl 1 tgf β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in caenorhabditis elegans |
| topic | innate immunity host response dbl-1 TGF-β C. elegans Smad |
| url | https://elifesciences.org/articles/75831 |
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