Congenital Giant Melanocytic Nevus with Malignant Melanoma of the Pleura: Do Primary Pleural Melanomas Exist?
Cases of primary pleural and bronchial melanoma have been described in the literature in the absence of melanocytic cells in the pleura and bronchi. We described a case of congenital giant melanocytic nevus that had a presentation suggestive of primary pleural melanoma. However, biopsy of a chest...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2017-09-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/595/330 |
| Summary: | Cases of primary pleural and bronchial melanoma have been described in the
literature in the absence of melanocytic cells in the pleura and bronchi. We described
a case of congenital giant melanocytic nevus that had a presentation suggestive of primary
pleural melanoma. However, biopsy of a chest wall lesion confirmed the presence of
another melanoma deposit in a subcutaneous swelling concealed within the congenital
giant melanocytic nevus. Histopathology with immunohistochemistry results showed
that the pleural and chest wall swelling were similar. The difficult clinical detection of
the primary tumor contributes to the fact that 24% of cases of congenital giant
melanocytic nevus receive a diagnosis of metastatic melanoma without identification
of the primary site. We propose that it is probable that the entity “primary pleural
melanoma” may, in fact, not exist. Instead, all such reported tumors in the pleura may
actually be metastatic from an unknown, regressed, or missed primary site. |
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| ISSN: | 2008-6709 2008-6687 |