Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report
Atypical hemolytic uremic syndrome (aHUS) is a rare and life-threatening disease that is associated with high mortality and morbidity. The incidence of aHUS is about 1 or 2 cases per 1,000,000 per year. Etiology can be either familial or sporadic. The pathogenesis of aHUS involves dysregulation of t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=283;epage=286;aulast=Vaidya |
| _version_ | 1811200612647305216 |
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| author | Ashwinkumar Vaidya Isha Polavarapu Ravindra Attur Prabhu Ganesh Mohan Shamee Shastry P A Prethika |
| author_facet | Ashwinkumar Vaidya Isha Polavarapu Ravindra Attur Prabhu Ganesh Mohan Shamee Shastry P A Prethika |
| author_sort | Ashwinkumar Vaidya |
| collection | DOAJ |
| description | Atypical hemolytic uremic syndrome (aHUS) is a rare and life-threatening disease that is associated with high mortality and morbidity. The incidence of aHUS is about 1 or 2 cases per 1,000,000 per year. Etiology can be either familial or sporadic. The pathogenesis of aHUS involves dysregulation of the alternative complement pathway, with predisposing mutations in complement genes. aHUS has a poor prognosis and a gradual or a relapsing (30%–86%) clinical course. The disease may present at any age but is mostly seen in children and young adults. Therapeutic plasma exchange (TPE) is one of the primary modalities of treatment in aHUS. This report presents the utilization of cascade plasmapheresis and its advantages over TPE in a patient with relapsed aHUS. There was a 73% decrement in antifactor H antibody levels following cascade plasmapheresis. |
| first_indexed | 2024-04-12T02:06:30Z |
| format | Article |
| id | doaj.art-151c878888464089a834de9f328d0ef5 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-12T02:06:30Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-151c878888464089a834de9f328d0ef52022-12-22T03:52:30ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652022-01-0116228328610.4103/ajts.ajts_121_21Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case reportAshwinkumar VaidyaIsha PolavarapuRavindra Attur PrabhuGanesh MohanShamee ShastryP A PrethikaAtypical hemolytic uremic syndrome (aHUS) is a rare and life-threatening disease that is associated with high mortality and morbidity. The incidence of aHUS is about 1 or 2 cases per 1,000,000 per year. Etiology can be either familial or sporadic. The pathogenesis of aHUS involves dysregulation of the alternative complement pathway, with predisposing mutations in complement genes. aHUS has a poor prognosis and a gradual or a relapsing (30%–86%) clinical course. The disease may present at any age but is mostly seen in children and young adults. Therapeutic plasma exchange (TPE) is one of the primary modalities of treatment in aHUS. This report presents the utilization of cascade plasmapheresis and its advantages over TPE in a patient with relapsed aHUS. There was a 73% decrement in antifactor H antibody levels following cascade plasmapheresis.http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=283;epage=286;aulast=Vaidyaatypical hemolytic uremic syndromecascade plasmapheresisthrombotic microangiopathy |
| spellingShingle | Ashwinkumar Vaidya Isha Polavarapu Ravindra Attur Prabhu Ganesh Mohan Shamee Shastry P A Prethika Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report Asian Journal of Transfusion Science atypical hemolytic uremic syndrome cascade plasmapheresis thrombotic microangiopathy |
| title | Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report |
| title_full | Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report |
| title_fullStr | Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report |
| title_full_unstemmed | Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report |
| title_short | Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report |
| title_sort | efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome a case report |
| topic | atypical hemolytic uremic syndrome cascade plasmapheresis thrombotic microangiopathy |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=283;epage=286;aulast=Vaidya |
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