Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders
Background: Since depression, sex hormones, and fatty acid status are interrelated, it is important to understand their relationships. In this study, we aimed to investigate sex differences in erythrocyte membrane fatty acid composition among first-diagnosed, drug-naïve patients with major depressiv...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1314151/full |
| _version_ | 1797387777266941952 |
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| author | Lu Wang Lu Wang Lu Wang Ting Liu Ting Liu Jimin Guo Tingyu Zhao Tingyu Zhao Hui Tang Fang Dong Fang Dong Chuanyue Wang Chuanyue Wang Jindong Chen Mimi Tang Mimi Tang |
| author_facet | Lu Wang Lu Wang Lu Wang Ting Liu Ting Liu Jimin Guo Tingyu Zhao Tingyu Zhao Hui Tang Fang Dong Fang Dong Chuanyue Wang Chuanyue Wang Jindong Chen Mimi Tang Mimi Tang |
| author_sort | Lu Wang |
| collection | DOAJ |
| description | Background: Since depression, sex hormones, and fatty acid status are interrelated, it is important to understand their relationships. In this study, we aimed to investigate sex differences in erythrocyte membrane fatty acid composition among first-diagnosed, drug-naïve patients with major depressive disorders.Methods: The study included 139 individuals with first-diagnosed, drug-naïve depression (male/female = 48/91) and 55 healthy controls (male/female = 24/31). The levels of erythrocyte membrane fatty acids were analyzed to compare the difference between males and females in both patients with depression and healthy controls, as well as to study their correlation with depressive symptoms.Results: In first-diagnosed, drug-naïve patients with major depressive disorders, sex disparities were observed in the levels of erythrocyte saturated fatty acids (SFAs) and n-6 PUFAs (such as C18:0, C20:4n6 and C22:4n6), where higher levels evident in females compared to in males. We found a noteworthy correlation between fatty acid levels and depressive symptoms, in which there is a significant association between female patients and depression but a weaker association between male patients and depression.Conclusion: Our findings demonstrate higher levels of n-6 PUFAs and SFAs in female patients with depression. The relationship between fatty acid composition and depressive symptoms was more prominent in females than males. These findings highlight the significance of considering sex as a crucial and interconnected factor in future investigations and potential adjunctive treatment for mood disorders by targeting fatty acid metabolism. |
| first_indexed | 2024-03-08T22:30:00Z |
| format | Article |
| id | doaj.art-151d1d94c71249e5b133ba0b8241d0f5 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T22:30:00Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-151d1d94c71249e5b133ba0b8241d0f52023-12-18T04:34:09ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.13141511314151Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disordersLu Wang0Lu Wang1Lu Wang2Ting Liu3Ting Liu4Jimin Guo5Tingyu Zhao6Tingyu Zhao7Hui Tang8Fang Dong9Fang Dong10Chuanyue Wang11Chuanyue Wang12Jindong Chen13Mimi Tang14Mimi Tang15The National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaCollege of Materials Sciences and Engineering, Beijing University of Chemical Technology, Beijing, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaThe National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaNational Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaBackground: Since depression, sex hormones, and fatty acid status are interrelated, it is important to understand their relationships. In this study, we aimed to investigate sex differences in erythrocyte membrane fatty acid composition among first-diagnosed, drug-naïve patients with major depressive disorders.Methods: The study included 139 individuals with first-diagnosed, drug-naïve depression (male/female = 48/91) and 55 healthy controls (male/female = 24/31). The levels of erythrocyte membrane fatty acids were analyzed to compare the difference between males and females in both patients with depression and healthy controls, as well as to study their correlation with depressive symptoms.Results: In first-diagnosed, drug-naïve patients with major depressive disorders, sex disparities were observed in the levels of erythrocyte saturated fatty acids (SFAs) and n-6 PUFAs (such as C18:0, C20:4n6 and C22:4n6), where higher levels evident in females compared to in males. We found a noteworthy correlation between fatty acid levels and depressive symptoms, in which there is a significant association between female patients and depression but a weaker association between male patients and depression.Conclusion: Our findings demonstrate higher levels of n-6 PUFAs and SFAs in female patients with depression. The relationship between fatty acid composition and depressive symptoms was more prominent in females than males. These findings highlight the significance of considering sex as a crucial and interconnected factor in future investigations and potential adjunctive treatment for mood disorders by targeting fatty acid metabolism.https://www.frontiersin.org/articles/10.3389/fphar.2023.1314151/fullmajor depression disordererythrocyte membrane fatty acidssex differencesn-6 PUFAsn-3 PUFAs |
| spellingShingle | Lu Wang Lu Wang Lu Wang Ting Liu Ting Liu Jimin Guo Tingyu Zhao Tingyu Zhao Hui Tang Fang Dong Fang Dong Chuanyue Wang Chuanyue Wang Jindong Chen Mimi Tang Mimi Tang Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders Frontiers in Pharmacology major depression disorder erythrocyte membrane fatty acids sex differences n-6 PUFAs n-3 PUFAs |
| title | Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders |
| title_full | Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders |
| title_fullStr | Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders |
| title_full_unstemmed | Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders |
| title_short | Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders |
| title_sort | sex differences in erythrocyte fatty acid composition of first diagnosed drug naive patients with major depressive disorders |
| topic | major depression disorder erythrocyte membrane fatty acids sex differences n-6 PUFAs n-3 PUFAs |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1314151/full |
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