Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response
Abstract SARS‐CoV‐2 specific T‐cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS‐CoV‐2 specific T‐cell response with antibody levels in...
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Clinical and Translational Medicine |
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| Online Access: | https://doi.org/10.1002/ctm2.802 |
| _version_ | 1828789820226273280 |
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| author | Alberto Pérez‐Gómez Carmen Gasca‐Capote Joana Vitallé Francisco J. Ostos Ana Serna‐Gallego María Trujillo‐Rodríguez Esperanza Muñoz‐Muela Teresa Giráldez‐Pérez Julia Praena‐Segovia María D. Navarro‐Amuedo María Paniagua‐García Manuel García‐Gutiérrez Manuela Aguilar‐Guisado Inmaculada Rivas‐Jeremías María Reyes Jiménez‐León Sara Bachiller Alberto Fernández‐Villar Alexandre Pérez‐González Alicia Gutiérrez‐Valencia Mohammed Rafii‐El‐Idrissi Benhnia Daniela Weiskopf Alessandro Sette Luis F. López‐Cortés Eva Poveda Ezequiel Ruiz‐Mateos Virgen del Rocío Hospital COVID‐19 and COHVID‐GS Working Teams |
| author_facet | Alberto Pérez‐Gómez Carmen Gasca‐Capote Joana Vitallé Francisco J. Ostos Ana Serna‐Gallego María Trujillo‐Rodríguez Esperanza Muñoz‐Muela Teresa Giráldez‐Pérez Julia Praena‐Segovia María D. Navarro‐Amuedo María Paniagua‐García Manuel García‐Gutiérrez Manuela Aguilar‐Guisado Inmaculada Rivas‐Jeremías María Reyes Jiménez‐León Sara Bachiller Alberto Fernández‐Villar Alexandre Pérez‐González Alicia Gutiérrez‐Valencia Mohammed Rafii‐El‐Idrissi Benhnia Daniela Weiskopf Alessandro Sette Luis F. López‐Cortés Eva Poveda Ezequiel Ruiz‐Mateos Virgen del Rocío Hospital COVID‐19 and COHVID‐GS Working Teams |
| author_sort | Alberto Pérez‐Gómez |
| collection | DOAJ |
| description | Abstract SARS‐CoV‐2 specific T‐cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS‐CoV‐2 specific T‐cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T‐cell polyfunctionality biased to IL‐2 production and inversely correlated with anti‐S IgG levels, combinations only including IFN‐γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non‐hospitalised and previously hospitalised patients presented robust anti‐S IgG levels and SARS‐CoV‐2 specific T‐cell response. In addition, only previously hospitalised patients showed a T‐cell exhaustion profile. Finally, combinations including IL‐2 in response to S protein of endemic coronaviruses were the ones associated with SARS‐CoV‐2 S‐specific T‐cell response in pre‐COVID‐19 healthy donors’ samples. These results could have implications for protective immunity against SARS‐CoV‐2 and recurrent COVID‐19 and may help for the design of new prototypes and boosting vaccine strategies. |
| first_indexed | 2024-12-12T01:19:38Z |
| format | Article |
| id | doaj.art-151fa4595b4d4cc1bf9eb48405abb07b |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-12-12T01:19:38Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-151fa4595b4d4cc1bf9eb48405abb07b2022-12-22T00:43:15ZengWileyClinical and Translational Medicine2001-13262022-04-01124n/an/a10.1002/ctm2.802Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous responseAlberto Pérez‐Gómez0Carmen Gasca‐Capote1Joana Vitallé2Francisco J. Ostos3Ana Serna‐Gallego4María Trujillo‐Rodríguez5Esperanza Muñoz‐Muela6Teresa Giráldez‐Pérez7Julia Praena‐Segovia8María D. Navarro‐Amuedo9María Paniagua‐García10Manuel García‐Gutiérrez11Manuela Aguilar‐Guisado12Inmaculada Rivas‐Jeremías13María Reyes Jiménez‐León14Sara Bachiller15Alberto Fernández‐Villar16Alexandre Pérez‐González17Alicia Gutiérrez‐Valencia18Mohammed Rafii‐El‐Idrissi Benhnia19Daniela Weiskopf20Alessandro Sette21Luis F. López‐Cortés22Eva Poveda23Ezequiel Ruiz‐Mateos24Virgen del Rocío Hospital COVID‐19 and COHVID‐GS Working Teams25Clinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainPneumology Service Galicia Sur Health Research Instituto (IIS Galicia Sur) Complexo Hospitalario Universitario de Vigo SERGAS‐UVigo Vigo SpainGroup of Virology and Pathogenesis Galicia Sur Health Research Institute (IIS Galicia Sur) Complexo Hospitalario Universitario de Vigo SERGAS‐UVigo Vigo SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainCenter for Infectious Disease and Vaccine Research La Jolla Institute for Immunology (LJI) La Jolla California USACenter for Infectious Disease and Vaccine Research La Jolla Institute for Immunology (LJI) La Jolla California USAClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainGroup of Virology and Pathogenesis Galicia Sur Health Research Institute (IIS Galicia Sur) Complexo Hospitalario Universitario de Vigo SERGAS‐UVigo Vigo SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainClinical Unit of Infectious Diseases Microbiology and Preventive Medicine Institute of Biomedicine of Seville (IBiS) Virgen del Rocío University Hospital CSIC University of Seville Seville SpainAbstract SARS‐CoV‐2 specific T‐cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS‐CoV‐2 specific T‐cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T‐cell polyfunctionality biased to IL‐2 production and inversely correlated with anti‐S IgG levels, combinations only including IFN‐γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non‐hospitalised and previously hospitalised patients presented robust anti‐S IgG levels and SARS‐CoV‐2 specific T‐cell response. In addition, only previously hospitalised patients showed a T‐cell exhaustion profile. Finally, combinations including IL‐2 in response to S protein of endemic coronaviruses were the ones associated with SARS‐CoV‐2 S‐specific T‐cell response in pre‐COVID‐19 healthy donors’ samples. These results could have implications for protective immunity against SARS‐CoV‐2 and recurrent COVID‐19 and may help for the design of new prototypes and boosting vaccine strategies.https://doi.org/10.1002/ctm2.802COVID‐19endemic coronavirusesIL‐2nucleocapsidpolyfunctionalitySARS‐CoV‐2 |
| spellingShingle | Alberto Pérez‐Gómez Carmen Gasca‐Capote Joana Vitallé Francisco J. Ostos Ana Serna‐Gallego María Trujillo‐Rodríguez Esperanza Muñoz‐Muela Teresa Giráldez‐Pérez Julia Praena‐Segovia María D. Navarro‐Amuedo María Paniagua‐García Manuel García‐Gutiérrez Manuela Aguilar‐Guisado Inmaculada Rivas‐Jeremías María Reyes Jiménez‐León Sara Bachiller Alberto Fernández‐Villar Alexandre Pérez‐González Alicia Gutiérrez‐Valencia Mohammed Rafii‐El‐Idrissi Benhnia Daniela Weiskopf Alessandro Sette Luis F. López‐Cortés Eva Poveda Ezequiel Ruiz‐Mateos Virgen del Rocío Hospital COVID‐19 and COHVID‐GS Working Teams Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response Clinical and Translational Medicine COVID‐19 endemic coronaviruses IL‐2 nucleocapsid polyfunctionality SARS‐CoV‐2 |
| title | Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response |
| title_full | Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response |
| title_fullStr | Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response |
| title_full_unstemmed | Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response |
| title_short | Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response |
| title_sort | deciphering the quality of sars cov 2 specific t cell response associated with disease severity immune memory and heterologous response |
| topic | COVID‐19 endemic coronaviruses IL‐2 nucleocapsid polyfunctionality SARS‐CoV‐2 |
| url | https://doi.org/10.1002/ctm2.802 |
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