Sarcopenia and COVID-19 Outcomes
Yuhan Wang, Shuwen Tan, Qihui Yan, Ying Gao Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Ying Gao, Department of Endocrinology and Metabolism, The First Hospital of Jilin University, No. 1 Xinmin Street, Chan...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-03-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/sarcopenia-and-covid-19-outcomes-peer-reviewed-fulltext-article-CIA |
| _version_ | 1811155589972099072 |
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| author | Wang Y Tan S Yan Q Gao Y |
| author_facet | Wang Y Tan S Yan Q Gao Y |
| author_sort | Wang Y |
| collection | DOAJ |
| description | Yuhan Wang, Shuwen Tan, Qihui Yan, Ying Gao Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Ying Gao, Department of Endocrinology and Metabolism, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, Jilin, 130021, People’s Republic of China, Tel +86-15804300435, Email g_y@jlu.edu.cnAbstract: Coronavirus disease 2019 (COVID-19) spread rapidly and became a severe global public health threat. Older adults have a high risk of COVID-19 and its associated mortality. Sarcopenia has emerged as a predictor of poor outcomes in COVID-19 patients, including lengthy hospital stays, mortality, intensive care unit admission, need for invasive mechanical ventilation, and poor rehabilitation outcomes. Chronic inflammation, immune dysfunction, respiratory muscle dysfunction, and swallowing dysfunction may underlie the association between sarcopenia and the poor outcomes of COVID-19 patients. Interleukin 6 receptor blockers (tocilizumab or sarilumab) are recommended for treating patients with severe COVID-19, and their therapeutic effects on sarcopenia are of great interest. This review aimed to analyze the current reports on the association between sarcopenia and COVID-19 and provide an update on the contribution of sarcopenia to the severity and adverse outcomes of COVID-19 and its underlying mechanisms. We also aimed to explore the different screening tools for sarcopenia concurrent with COVID-19, and advocate for early diagnosis and treatment of sarcopenia. Given that the fight against the COVID-19 pandemic may be long-term, further research into understanding the effects of sarcopenia in patients infected with the Omicron variant is necessary.Keywords: COVID-19, sarcopenia, skeletal muscle, inflammation, IL-6 |
| first_indexed | 2024-04-10T04:37:06Z |
| format | Article |
| id | doaj.art-1520abca87f94ed6825b15f0b960ac99 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-04-10T04:37:06Z |
| publishDate | 2023-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-1520abca87f94ed6825b15f0b960ac992023-03-09T16:47:04ZengDove Medical PressClinical Interventions in Aging1178-19982023-03-01Volume 1835937382139Sarcopenia and COVID-19 OutcomesWang YTan SYan QGao YYuhan Wang, Shuwen Tan, Qihui Yan, Ying Gao Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Ying Gao, Department of Endocrinology and Metabolism, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, Jilin, 130021, People’s Republic of China, Tel +86-15804300435, Email g_y@jlu.edu.cnAbstract: Coronavirus disease 2019 (COVID-19) spread rapidly and became a severe global public health threat. Older adults have a high risk of COVID-19 and its associated mortality. Sarcopenia has emerged as a predictor of poor outcomes in COVID-19 patients, including lengthy hospital stays, mortality, intensive care unit admission, need for invasive mechanical ventilation, and poor rehabilitation outcomes. Chronic inflammation, immune dysfunction, respiratory muscle dysfunction, and swallowing dysfunction may underlie the association between sarcopenia and the poor outcomes of COVID-19 patients. Interleukin 6 receptor blockers (tocilizumab or sarilumab) are recommended for treating patients with severe COVID-19, and their therapeutic effects on sarcopenia are of great interest. This review aimed to analyze the current reports on the association between sarcopenia and COVID-19 and provide an update on the contribution of sarcopenia to the severity and adverse outcomes of COVID-19 and its underlying mechanisms. We also aimed to explore the different screening tools for sarcopenia concurrent with COVID-19, and advocate for early diagnosis and treatment of sarcopenia. Given that the fight against the COVID-19 pandemic may be long-term, further research into understanding the effects of sarcopenia in patients infected with the Omicron variant is necessary.Keywords: COVID-19, sarcopenia, skeletal muscle, inflammation, IL-6https://www.dovepress.com/sarcopenia-and-covid-19-outcomes-peer-reviewed-fulltext-article-CIAcovid-19sarcopeniaskeletal muscleinflammationil-6 |
| spellingShingle | Wang Y Tan S Yan Q Gao Y Sarcopenia and COVID-19 Outcomes Clinical Interventions in Aging covid-19 sarcopenia skeletal muscle inflammation il-6 |
| title | Sarcopenia and COVID-19 Outcomes |
| title_full | Sarcopenia and COVID-19 Outcomes |
| title_fullStr | Sarcopenia and COVID-19 Outcomes |
| title_full_unstemmed | Sarcopenia and COVID-19 Outcomes |
| title_short | Sarcopenia and COVID-19 Outcomes |
| title_sort | sarcopenia and covid 19 outcomes |
| topic | covid-19 sarcopenia skeletal muscle inflammation il-6 |
| url | https://www.dovepress.com/sarcopenia-and-covid-19-outcomes-peer-reviewed-fulltext-article-CIA |
| work_keys_str_mv | AT wangy sarcopeniaandcovid19outcomes AT tans sarcopeniaandcovid19outcomes AT yanq sarcopeniaandcovid19outcomes AT gaoy sarcopeniaandcovid19outcomes |