Growth Hormone–Releaser Diet Attenuates β-Amyloid(1-42)–Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice
We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)–induced memory impairment, but the underlying mechanism remained to be characterized. We show here that the GH-releaser diet significantly attenuated Aβ(1-42)-induced impairment in context-depende...
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| Format: | Article |
| Language: | English |
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Elsevier
2009-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319340927 |
| _version_ | 1818790370902802432 |
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| author | Eun-Joo Shin Jong Seok Chae Seok Joo Park Sun Cheol Kim Kyo Hwan Koo Kiyofumi Yamada Toshitaka Nabeshima Hyoung-Chun Kim |
| author_facet | Eun-Joo Shin Jong Seok Chae Seok Joo Park Sun Cheol Kim Kyo Hwan Koo Kiyofumi Yamada Toshitaka Nabeshima Hyoung-Chun Kim |
| author_sort | Eun-Joo Shin |
| collection | DOAJ |
| description | We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)–induced memory impairment, but the underlying mechanism remained to be characterized. We show here that the GH-releaser diet significantly attenuated Aβ(1-42)-induced impairment in context-dependent conditioned fear, with a reduction in GH levels and changes in hippocampal acetylcholine, acetylcholinesterase, choline acetyltransferase, insulin-like growth factor (IGF)-1, and IGF-1–receptor activity in mice. JB-1, an IGF-1–receptor antagonist, significantly blocked GH-releaser diet–mediated pharmacological actions. Our results suggest that the GH-releaser diet prevents Aβ(1-42)-induced cognitive deficits via stimulation of the hippocampal IGF-1 receptor. Keywords:: growth hormone releaser, β-amyloid, insulin-like growth factor (IGF)-1 receptor |
| first_indexed | 2024-12-18T14:54:23Z |
| format | Article |
| id | doaj.art-1522e76e5afc42a5a6f036519d7462ba |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-18T14:54:23Z |
| publishDate | 2009-01-01 |
| publisher | Elsevier |
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| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-1522e76e5afc42a5a6f036519d7462ba2022-12-21T21:04:05ZengElsevierJournal of Pharmacological Sciences1347-86132009-01-011091139143Growth Hormone–Releaser Diet Attenuates β-Amyloid(1-42)–Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in MiceEun-Joo Shin0Jong Seok Chae1Seok Joo Park2Sun Cheol Kim3Kyo Hwan Koo4Kiyofumi Yamada5Toshitaka Nabeshima6Hyoung-Chun Kim7Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaDepartment of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8550, JapanDepartment of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya 468-8503, JapanNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea; Corresponding author. kimhc@kangwon.ac.krWe previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)–induced memory impairment, but the underlying mechanism remained to be characterized. We show here that the GH-releaser diet significantly attenuated Aβ(1-42)-induced impairment in context-dependent conditioned fear, with a reduction in GH levels and changes in hippocampal acetylcholine, acetylcholinesterase, choline acetyltransferase, insulin-like growth factor (IGF)-1, and IGF-1–receptor activity in mice. JB-1, an IGF-1–receptor antagonist, significantly blocked GH-releaser diet–mediated pharmacological actions. Our results suggest that the GH-releaser diet prevents Aβ(1-42)-induced cognitive deficits via stimulation of the hippocampal IGF-1 receptor. Keywords:: growth hormone releaser, β-amyloid, insulin-like growth factor (IGF)-1 receptorhttp://www.sciencedirect.com/science/article/pii/S1347861319340927 |
| spellingShingle | Eun-Joo Shin Jong Seok Chae Seok Joo Park Sun Cheol Kim Kyo Hwan Koo Kiyofumi Yamada Toshitaka Nabeshima Hyoung-Chun Kim Growth Hormone–Releaser Diet Attenuates β-Amyloid(1-42)–Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice Journal of Pharmacological Sciences |
| title | Growth Hormone–Releaser Diet Attenuates β-Amyloid(1-42)–Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice |
| title_full | Growth Hormone–Releaser Diet Attenuates β-Amyloid(1-42)–Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice |
| title_fullStr | Growth Hormone–Releaser Diet Attenuates β-Amyloid(1-42)–Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice |
| title_full_unstemmed | Growth Hormone–Releaser Diet Attenuates β-Amyloid(1-42)–Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice |
| title_short | Growth Hormone–Releaser Diet Attenuates β-Amyloid(1-42)–Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice |
| title_sort | growth hormone releaser diet attenuates β amyloid 1 42 induced cognitive impairment via stimulation of the insulin like growth factor igf 1 receptor in mice |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319340927 |
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