Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma
Abstract Glioblastoma Multiforme (GBM) remains the most common malignant primary brain tumor with a dismal prognosis that rarely exceeds beyond 2 years despite extensive therapy, which consists of maximal safe surgical resection, radiotherapy, and/or chemotherapy. Recently, it has become clear that...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-05-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5681 |
| _version_ | 1827932342100951040 |
|---|---|
| author | B. Decraene M. Vanmechelen P. Clement J. F. Daisne I. Vanden Bempt R. Sciot A. D. Garg P. Agostinis F. De Smet S. De Vleeschouwer |
| author_facet | B. Decraene M. Vanmechelen P. Clement J. F. Daisne I. Vanden Bempt R. Sciot A. D. Garg P. Agostinis F. De Smet S. De Vleeschouwer |
| author_sort | B. Decraene |
| collection | DOAJ |
| description | Abstract Glioblastoma Multiforme (GBM) remains the most common malignant primary brain tumor with a dismal prognosis that rarely exceeds beyond 2 years despite extensive therapy, which consists of maximal safe surgical resection, radiotherapy, and/or chemotherapy. Recently, it has become clear that GBM is not one homogeneous entity and that both intra‐and intertumoral heterogeneity contributes significantly to differences in tumoral behavior which may consequently be responsible for differences in survival. Strikingly and in spite of its dismal prognosis, small fractions of GBM patients seem to display extremely long survival, defined as surviving over 10 years after diagnosis, compared to the large majority of patients. Although the underlying mechanisms for this peculiarity remain largely unknown, emerging data suggest that still poorly characterized both cellular and molecular factors of the tumor microenvironment and their interplay probably play an important role. We hereby give an extensive overview of what is yet known about these cellular and molecular features shaping extreme long survival in GBM. |
| first_indexed | 2024-03-13T07:07:13Z |
| format | Article |
| id | doaj.art-1525ca1bfd33402981e57cde4949d51c |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-13T07:07:13Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-1525ca1bfd33402981e57cde4949d51c2023-06-06T07:30:47ZengWileyCancer Medicine2045-76342023-05-011210111071112610.1002/cam4.5681Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastomaB. Decraene0M. Vanmechelen1P. Clement2J. F. Daisne3I. Vanden Bempt4R. Sciot5A. D. Garg6P. Agostinis7F. De Smet8S. De Vleeschouwer9KU Leuven, Laboratory for Precision Cancer Medicine Translational Cell and Tissue Research Unit Leuven BelgiumKU Leuven, Laboratory for Precision Cancer Medicine Translational Cell and Tissue Research Unit Leuven BelgiumDepartment of General Medical Oncology University Hospitals Leuven Leuven BelgiumRadiation Oncology Department University Hospitals Leuven Leuven BelgiumDepartment of Human Genetics University Hospitals Leuven Leuven BelgiumDepartment of Pathology University Hospitals Leuven Leuven BelgiumKU Leuven, Laboratory of Cell Stress & Immunity (CSI), Department of Cellular & Molecular Medicine Leuven BelgiumCell Death Research and Therapy Group Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium VIB Center for Cancer Biology, 3000 Leuven BelgiumKU Leuven, Laboratory for Precision Cancer Medicine Translational Cell and Tissue Research Unit Leuven BelgiumKU Leuven Department of Neurosciences Experimental Neurosurgery and Neuroanatomy Research Group Leuven BelgiumAbstract Glioblastoma Multiforme (GBM) remains the most common malignant primary brain tumor with a dismal prognosis that rarely exceeds beyond 2 years despite extensive therapy, which consists of maximal safe surgical resection, radiotherapy, and/or chemotherapy. Recently, it has become clear that GBM is not one homogeneous entity and that both intra‐and intertumoral heterogeneity contributes significantly to differences in tumoral behavior which may consequently be responsible for differences in survival. Strikingly and in spite of its dismal prognosis, small fractions of GBM patients seem to display extremely long survival, defined as surviving over 10 years after diagnosis, compared to the large majority of patients. Although the underlying mechanisms for this peculiarity remain largely unknown, emerging data suggest that still poorly characterized both cellular and molecular factors of the tumor microenvironment and their interplay probably play an important role. We hereby give an extensive overview of what is yet known about these cellular and molecular features shaping extreme long survival in GBM.https://doi.org/10.1002/cam4.5681gbmglioblastomalong‐term survivorsmolecular markers |
| spellingShingle | B. Decraene M. Vanmechelen P. Clement J. F. Daisne I. Vanden Bempt R. Sciot A. D. Garg P. Agostinis F. De Smet S. De Vleeschouwer Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma Cancer Medicine gbm glioblastoma long‐term survivors molecular markers |
| title | Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma |
| title_full | Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma |
| title_fullStr | Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma |
| title_full_unstemmed | Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma |
| title_short | Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma |
| title_sort | cellular and molecular features related to exceptional therapy response and extreme long term survival in glioblastoma |
| topic | gbm glioblastoma long‐term survivors molecular markers |
| url | https://doi.org/10.1002/cam4.5681 |
| work_keys_str_mv | AT bdecraene cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT mvanmechelen cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT pclement cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT jfdaisne cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT ivandenbempt cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT rsciot cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT adgarg cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT pagostinis cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT fdesmet cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma AT sdevleeschouwer cellularandmolecularfeaturesrelatedtoexceptionaltherapyresponseandextremelongtermsurvivalinglioblastoma |