Impact of Lipoprotein(a) on Macrovascular Complications of Diabetes in a Multiethnic Population in the French Amazon
Background and Aims. In French Guiana, the prevalence of diabetes is around 10%, and cardio and neurovascular pathologies are the first medical cause of early mortality. Lipoprotein(a) (Lp(a)) is described in the literature as a risk factor independent of other cardiovascular risk factors, but there...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2023/8111521 |
| _version_ | 1811165456248078336 |
|---|---|
| author | Sabrina Dordonne Mayka Mergeayfabre Nezha Hafsi Andre Ntoutoum Clara Salazar-Cardozo Olivier Casse Marianne Hounnou Antoine Adenis Jean-Markens Aurelus Caroline Misslin-Tristch Jean-François Carod Bertrand De Toffol Jean François Lienne Magalie Demar Mathieu Nacher Nadia Sabbah |
| author_facet | Sabrina Dordonne Mayka Mergeayfabre Nezha Hafsi Andre Ntoutoum Clara Salazar-Cardozo Olivier Casse Marianne Hounnou Antoine Adenis Jean-Markens Aurelus Caroline Misslin-Tristch Jean-François Carod Bertrand De Toffol Jean François Lienne Magalie Demar Mathieu Nacher Nadia Sabbah |
| author_sort | Sabrina Dordonne |
| collection | DOAJ |
| description | Background and Aims. In French Guiana, the prevalence of diabetes is around 10%, and cardio and neurovascular pathologies are the first medical cause of early mortality. Lipoprotein(a) (Lp(a)) is described in the literature as a risk factor independent of other cardiovascular risk factors, but there are important interindividual differences, especially according to ethnicity. The objective of this study was to investigate the association of Lp(a) and macrovascular complications in a multiethnic population of patients with diabetes in the French Amazon. Materials and Methods. Since May 2019, 1243 patients were screened 806 of whom had Lp(a) determination. We compared the prevalence of macrovascular complications in three groups according to Lp(a) concentration: between 0 and 75 mg/mL, between 76 and 300 mg/mL, and >300 mg/mL. Results. 712 patients in the study had type 2 diabetes (88.34% of the sample). A history of hypertension was significantly associated with greater Lp(a) levels. Lp(a) concentration was greater among Creole ethnic groups. No association was found between Lp(a) levels and macrovascular complications in the Lpa>300 mg/mL group. Conclusions. These results do not replicate findings in mostly Caucasian populations suggesting that the Lp(a) threshold for, or the link with, cardiovascular risk may be different given the predominantly African origin of the French Guianese population. Further studies should study genetic polymorphisms in our population. |
| first_indexed | 2024-04-10T15:37:22Z |
| format | Article |
| id | doaj.art-1526410f0d994efe8d3869e5c25e298f |
| institution | Directory Open Access Journal |
| issn | 2314-6753 |
| language | English |
| last_indexed | 2024-04-10T15:37:22Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj.art-1526410f0d994efe8d3869e5c25e298f2023-02-13T01:08:47ZengHindawi LimitedJournal of Diabetes Research2314-67532023-01-01202310.1155/2023/8111521Impact of Lipoprotein(a) on Macrovascular Complications of Diabetes in a Multiethnic Population in the French AmazonSabrina Dordonne0Mayka Mergeayfabre1Nezha Hafsi2Andre Ntoutoum3Clara Salazar-Cardozo4Olivier Casse5Marianne Hounnou6Antoine Adenis7Jean-Markens Aurelus8Caroline Misslin-Tristch9Jean-François Carod10Bertrand De Toffol11Jean François Lienne12Magalie Demar13Mathieu Nacher14Nadia Sabbah15Department of Endocrinology and Metabolic DiseasesClinical Investigation Center Antilles French Guiana (CIC INSERM 1424)Department of Endocrinology and Metabolic DiseasesDepartment of Endocrinology and Metabolic DiseasesClinical Investigation Center Antilles French Guiana (CIC INSERM 1424)Clinical Investigation Center Antilles French Guiana (CIC INSERM 1424)Department of Endocrinology and Metabolic DiseasesClinical Investigation Center Antilles French Guiana (CIC INSERM 1424)Department of Endocrinology and Metabolic DiseasesDepartment of General MedicineLaboratory of BiologyDepartment of NeurologyDepartment of Endocrinology and Metabolic DiseasesLaboratory of Parasitology-Mycology (LHUPM)Clinical Investigation Center Antilles French Guiana (CIC INSERM 1424)Department of Endocrinology and Metabolic DiseasesBackground and Aims. In French Guiana, the prevalence of diabetes is around 10%, and cardio and neurovascular pathologies are the first medical cause of early mortality. Lipoprotein(a) (Lp(a)) is described in the literature as a risk factor independent of other cardiovascular risk factors, but there are important interindividual differences, especially according to ethnicity. The objective of this study was to investigate the association of Lp(a) and macrovascular complications in a multiethnic population of patients with diabetes in the French Amazon. Materials and Methods. Since May 2019, 1243 patients were screened 806 of whom had Lp(a) determination. We compared the prevalence of macrovascular complications in three groups according to Lp(a) concentration: between 0 and 75 mg/mL, between 76 and 300 mg/mL, and >300 mg/mL. Results. 712 patients in the study had type 2 diabetes (88.34% of the sample). A history of hypertension was significantly associated with greater Lp(a) levels. Lp(a) concentration was greater among Creole ethnic groups. No association was found between Lp(a) levels and macrovascular complications in the Lpa>300 mg/mL group. Conclusions. These results do not replicate findings in mostly Caucasian populations suggesting that the Lp(a) threshold for, or the link with, cardiovascular risk may be different given the predominantly African origin of the French Guianese population. Further studies should study genetic polymorphisms in our population.http://dx.doi.org/10.1155/2023/8111521 |
| spellingShingle | Sabrina Dordonne Mayka Mergeayfabre Nezha Hafsi Andre Ntoutoum Clara Salazar-Cardozo Olivier Casse Marianne Hounnou Antoine Adenis Jean-Markens Aurelus Caroline Misslin-Tristch Jean-François Carod Bertrand De Toffol Jean François Lienne Magalie Demar Mathieu Nacher Nadia Sabbah Impact of Lipoprotein(a) on Macrovascular Complications of Diabetes in a Multiethnic Population in the French Amazon Journal of Diabetes Research |
| title | Impact of Lipoprotein(a) on Macrovascular Complications of Diabetes in a Multiethnic Population in the French Amazon |
| title_full | Impact of Lipoprotein(a) on Macrovascular Complications of Diabetes in a Multiethnic Population in the French Amazon |
| title_fullStr | Impact of Lipoprotein(a) on Macrovascular Complications of Diabetes in a Multiethnic Population in the French Amazon |
| title_full_unstemmed | Impact of Lipoprotein(a) on Macrovascular Complications of Diabetes in a Multiethnic Population in the French Amazon |
| title_short | Impact of Lipoprotein(a) on Macrovascular Complications of Diabetes in a Multiethnic Population in the French Amazon |
| title_sort | impact of lipoprotein a on macrovascular complications of diabetes in a multiethnic population in the french amazon |
| url | http://dx.doi.org/10.1155/2023/8111521 |
| work_keys_str_mv | AT sabrinadordonne impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT maykamergeayfabre impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT nezhahafsi impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT andrentoutoum impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT clarasalazarcardozo impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT oliviercasse impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT mariannehounnou impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT antoineadenis impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT jeanmarkensaurelus impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT carolinemisslintristch impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT jeanfrancoiscarod impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT bertranddetoffol impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT jeanfrancoislienne impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT magaliedemar impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT mathieunacher impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon AT nadiasabbah impactoflipoproteinaonmacrovascularcomplicationsofdiabetesinamultiethnicpopulationinthefrenchamazon |