Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion

Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion

Lysyl oxidase (LOX) is an enzyme critically involved in collagen maturation, whose activity releases H<sub>2</sub>O<sub>2</sub> as a by-product. Previous studies demonstrated that LOX over-expression enhances reactive oxygen species (ROS) production and exacerbates cardiac re...

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Bibliographic Details
Main Authors: Laura Valls-Lacalle, Lídia Puertas-Umbert, Saray Varona, José Martínez-González, Cristina Rodríguez, Antonio Rodríguez-Sinovas
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
lysyl oxidase
reperfusion injury
cardiac remodeling
Online Access:https://www.mdpi.com/2076-3921/11/1/75

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