ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis

ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis

The role of Situin 1 (SIRT1) in tumorigenesis is still controversial due to its wide range of substrates, including both oncoproteins and tumor suppressors. A recent study has demonstrated that SIRT1 interferes in the Kirsten rat sarcoma viral oncogene homolog (KRAS)-driven activation of the Raf-mit...

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Bibliographic Details
Main Authors: Ok-Seon Kwon, Haeseung Lee, Yun-Jeong Kim, Hyuk-Jin Cha, Na-Young Song, Mi-Ok Lee
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
SIRT1
RAS
ERK
MKP1
tumorigenesis
deacetylation
Online Access:https://www.mdpi.com/2072-6694/12/4/909

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