Analysis of the substrate recognition state of TDP-43 to single-stranded DNA using fluorescence correlation spectroscopy

Analysis of the substrate recognition state of TDP-43 to single-stranded DNA using fluorescence correlation spectroscopy

Normal function and abnormal aggregation of transactivation response (TAR) DNA/RNA-binding protein 43 kDa (TDP-43) are directly associated with the lethal genetic diseases: cystic fibrosis, amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD). The binding of TDP-43 to si...

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Bibliographic Details
Main Authors: Akira Kitamura, Ai Shibasaki, Kayo Takeda, Ryoji Suno, Masataka Kinjo
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Transactivation response DNA/RNA-binding protein 43 kDa
Dissociation constant
Binding stoichiometry
Fluorescence correlation spectroscopy
Electrophoretic mobility shift assay
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580818300554

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http://www.sciencedirect.com/science/article/pii/S2405580818300554

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