Effect of Atorvastatin on Memory in Albino Mice
Objective: The aim and objective of the present study was to evaluate the effect of atorvastatin on learning and memory in albino mice. Materials and Methods: Thirty Swiss albino mice were divided into 5groups (n=6). In group2, group4 and group5 hyperlipidemia was induced by high fat diet (HFD)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5089/9730_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(Sh)_PF2(PAG).pdf |
| Summary: | Objective: The aim and objective of the present study was to
evaluate the effect of atorvastatin on learning and memory in
albino mice.
Materials and Methods: Thirty Swiss albino mice were
divided into 5groups (n=6). In group2, group4 and group5
hyperlipidemia was induced by high fat diet (HFD) orally for
28days. Atrorvastatin was given to group3, group4 and group5
orally for 14 d. Learning and memory was evaluated with Hebb
Williams’s maze, Elevated plus maze, Y maze and Step through
latency. Continuous data were analyzed by one way ANOVA
followed by Scheffe multiple range test, discrete data were
analyzed by Kruskal - Wallis test. The level of significance was
5% (p ≤ 0.05).
Result and Conclusion: HFD treatment had shown significant
increase in body weight, significant impairment in learning and
memory (p < 0.05). Only atorvastatin treated group had shown
better learning and memory in comparison to HFD group.
Atorvastatin 10mg/kg and 20 mg/kg had reversed the HFD
induced impairment of learning and memory but there was no
significant difference between the doses (p > 0.05). |
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| ISSN: | 2249-782X 0973-709X |