Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode
It appeared that either the carbon paste or the screen-printed carbon electrodes that were modified with gold nanoparticles (AuNPs) gave rise to the largest current responses after a rapid screening of various nanomaterials as modifiers of carbon composite electrodes in view of designing an electroc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/20/10/2797 |
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| author | M. Shehata Amany M. Fekry Alain Walcarius |
| author_facet | M. Shehata Amany M. Fekry Alain Walcarius |
| author_sort | M. Shehata |
| collection | DOAJ |
| description | It appeared that either the carbon paste or the screen-printed carbon electrodes that were modified with gold nanoparticles (AuNPs) gave rise to the largest current responses after a rapid screening of various nanomaterials as modifiers of carbon composite electrodes in view of designing an electrochemical sensor for Moxifloxacin Hydrochloride (Moxi). The screen-printed electrode (SPE) support was preferred over the carbon paste one for its ability to be used as disposable single-use sensor enabling the circumvention of the problems of surface fouling encountered in the determination of Moxi. The response of AuNPs modified SPE to Moxi was investigated by cyclic voltammetry (CV) (including the effect of the potential scan rate and the pH of the medium), chronoamperometry, and differential pulse voltammetry (DPV) after morphological and physico-chemical characterization. DPV was finally applied to Moxi detection in phosphate buffer at pH 7, giving rise to an accessible concentration window ranging between 8 µM and 0.48 mM, and the detection and quantification limits were established to be 11.6 µM and 38.6 µM, correspondingly. In order to estimate the applicability of Moxi identification scheme in actual trials, it was practiced in a human baby urine sample with excellent recoveries between 99.8 % and 101.6 % and RSDs of 1.1–3.4%, without noticeable interference. |
| first_indexed | 2024-03-10T19:50:15Z |
| format | Article |
| id | doaj.art-1529dfa9a02a426a82e5fe6598edf9d3 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T19:50:15Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-1529dfa9a02a426a82e5fe6598edf9d32023-11-20T00:26:53ZengMDPI AGSensors1424-82202020-05-012010279710.3390/s20102797Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed ElectrodeM. Shehata0Amany M. Fekry1Alain Walcarius2Chemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptChemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptLCPME, Université de Lorraine, CNRS, F-54000 Nancy, FranceIt appeared that either the carbon paste or the screen-printed carbon electrodes that were modified with gold nanoparticles (AuNPs) gave rise to the largest current responses after a rapid screening of various nanomaterials as modifiers of carbon composite electrodes in view of designing an electrochemical sensor for Moxifloxacin Hydrochloride (Moxi). The screen-printed electrode (SPE) support was preferred over the carbon paste one for its ability to be used as disposable single-use sensor enabling the circumvention of the problems of surface fouling encountered in the determination of Moxi. The response of AuNPs modified SPE to Moxi was investigated by cyclic voltammetry (CV) (including the effect of the potential scan rate and the pH of the medium), chronoamperometry, and differential pulse voltammetry (DPV) after morphological and physico-chemical characterization. DPV was finally applied to Moxi detection in phosphate buffer at pH 7, giving rise to an accessible concentration window ranging between 8 µM and 0.48 mM, and the detection and quantification limits were established to be 11.6 µM and 38.6 µM, correspondingly. In order to estimate the applicability of Moxi identification scheme in actual trials, it was practiced in a human baby urine sample with excellent recoveries between 99.8 % and 101.6 % and RSDs of 1.1–3.4%, without noticeable interference.https://www.mdpi.com/1424-8220/20/10/2797Moxifloxacin hydrochloride (Moxi)carbon paste electrodescarbon screen-printed electrodesgold nanoparticles (AuNPs)modified electrodesdifferential pulse voltammetry |
| spellingShingle | M. Shehata Amany M. Fekry Alain Walcarius Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode Sensors Moxifloxacin hydrochloride (Moxi) carbon paste electrodes carbon screen-printed electrodes gold nanoparticles (AuNPs) modified electrodes differential pulse voltammetry |
| title | Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode |
| title_full | Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode |
| title_fullStr | Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode |
| title_full_unstemmed | Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode |
| title_short | Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode |
| title_sort | moxifloxacin hydrochloride electrochemical detection at gold nanoparticles modified screen printed electrode |
| topic | Moxifloxacin hydrochloride (Moxi) carbon paste electrodes carbon screen-printed electrodes gold nanoparticles (AuNPs) modified electrodes differential pulse voltammetry |
| url | https://www.mdpi.com/1424-8220/20/10/2797 |
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