Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis.
BACKGROUND: The opinion of application of indocyanine green (ICG) in the macular hole surgery was contradictory. Here we conducted a meta-analysis to evaluate the effect of in internal limiting membrane (ILM) peeling for macular hole surgery. METHODS AND FINDINGS: We searched electronic databases fo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3492355?pdf=render |
| _version_ | 1831567887294267392 |
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| author | Yan Wu Wei Zhu Ding Xu Yan-Hong Li Jun Ba Xiao-Long Zhang Fang Wang Jing Yu |
| author_facet | Yan Wu Wei Zhu Ding Xu Yan-Hong Li Jun Ba Xiao-Long Zhang Fang Wang Jing Yu |
| author_sort | Yan Wu |
| collection | DOAJ |
| description | BACKGROUND: The opinion of application of indocyanine green (ICG) in the macular hole surgery was contradictory. Here we conducted a meta-analysis to evaluate the effect of in internal limiting membrane (ILM) peeling for macular hole surgery. METHODS AND FINDINGS: We searched electronic databases for comparative studies published before July 2012 of ILM peeling with and without ICG. Twenty-two studies including 1585 eyes were included. Visual acuity (VA) improvement, including the postoperative rate of ≥20/40 VA gained (OR, 0.65; 95% CI, 0.43 to 0.97; P = 0.033) and increased LogMAR (WMD, -0.09; 95% CI, -0.16 to -0.02; P = 0.011), was less in the ICG group. The risk of visual field defects was greater in the ICG group than in the non-ICG group. There was no significant difference in the rate of anatomical outcomes between ILM peeling procedures performed with and without ICG. RPE changes and other postoperative complications were not significantly different between the ICG and non-ICG groups. An additional analysis showed that the VA improvement of the ICG group was less than the non-ICG group only within the first year of follow up. A subgroup analysis showed that the rate of VA improvement was lower in the ICG group than in other adjuncts group. A higher rate of secondary closure and less VA improvement were observed in a high proportion (>0.1%) of the ICG group. A sensitivity analysis after the randomized-controlled trials were excluded from the meta-analysis demonstrated no differences compared with the overall results. CONCLUSIONS: This meta-analysis demonstrated that there is no evidence of clinical superiority in outcomes for ICG-assisted ILM peeling procedure over the non-ICG one. The toxicity of ICG should be considered when choosing the various staining methods. |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T12:06:12Z |
| publishDate | 2012-01-01 |
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| spelling | doaj.art-1529f1a70f2e476698d785df74d1fdea2022-12-21T21:49:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4840510.1371/journal.pone.0048405Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis.Yan WuWei ZhuDing XuYan-Hong LiJun BaXiao-Long ZhangFang WangJing YuBACKGROUND: The opinion of application of indocyanine green (ICG) in the macular hole surgery was contradictory. Here we conducted a meta-analysis to evaluate the effect of in internal limiting membrane (ILM) peeling for macular hole surgery. METHODS AND FINDINGS: We searched electronic databases for comparative studies published before July 2012 of ILM peeling with and without ICG. Twenty-two studies including 1585 eyes were included. Visual acuity (VA) improvement, including the postoperative rate of ≥20/40 VA gained (OR, 0.65; 95% CI, 0.43 to 0.97; P = 0.033) and increased LogMAR (WMD, -0.09; 95% CI, -0.16 to -0.02; P = 0.011), was less in the ICG group. The risk of visual field defects was greater in the ICG group than in the non-ICG group. There was no significant difference in the rate of anatomical outcomes between ILM peeling procedures performed with and without ICG. RPE changes and other postoperative complications were not significantly different between the ICG and non-ICG groups. An additional analysis showed that the VA improvement of the ICG group was less than the non-ICG group only within the first year of follow up. A subgroup analysis showed that the rate of VA improvement was lower in the ICG group than in other adjuncts group. A higher rate of secondary closure and less VA improvement were observed in a high proportion (>0.1%) of the ICG group. A sensitivity analysis after the randomized-controlled trials were excluded from the meta-analysis demonstrated no differences compared with the overall results. CONCLUSIONS: This meta-analysis demonstrated that there is no evidence of clinical superiority in outcomes for ICG-assisted ILM peeling procedure over the non-ICG one. The toxicity of ICG should be considered when choosing the various staining methods.http://europepmc.org/articles/PMC3492355?pdf=render |
| spellingShingle | Yan Wu Wei Zhu Ding Xu Yan-Hong Li Jun Ba Xiao-Long Zhang Fang Wang Jing Yu Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis. PLoS ONE |
| title | Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis. |
| title_full | Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis. |
| title_fullStr | Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis. |
| title_full_unstemmed | Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis. |
| title_short | Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis. |
| title_sort | indocyanine green assisted internal limiting membrane peeling in macular hole surgery a meta analysis |
| url | http://europepmc.org/articles/PMC3492355?pdf=render |
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