A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant
IntroductionMyocardial injury in elderly Omicron variant patients is a leading cause of severe disease and death. This study focuses on elucidating the clinical characteristics and potential risk factors associated with myocardial injury in elderly patients infected with the Omicron variant.MethodsM...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1268499/full |
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| author | Xueying Yu Xiaoguang Li Shuai Xia Lu Lu Jiahui Fan Ying Wang Yan Fu Chen Suo Qiuhong Man Lize Xiong Lize Xiong |
| author_facet | Xueying Yu Xiaoguang Li Shuai Xia Lu Lu Jiahui Fan Ying Wang Yan Fu Chen Suo Qiuhong Man Lize Xiong Lize Xiong |
| author_sort | Xueying Yu |
| collection | DOAJ |
| description | IntroductionMyocardial injury in elderly Omicron variant patients is a leading cause of severe disease and death. This study focuses on elucidating the clinical characteristics and potential risk factors associated with myocardial injury in elderly patients infected with the Omicron variant.MethodsMyocardial injury was defined based on elevated cardiac troponin concentrations exceeding the 99th percentile upper reference limit. Among 772 elderly Omicron-infected patients, categorized into myocardial injury (n = 263) and non-myocardial injury (n = 509) groups. The stratified log-rank statistic was used to compare the probability of patients developing intensive care. Receiver operating characteristic curves were used to determine the best cut-off values of clinical and laboratory data for predicting myocardial injury. Univariate and multivariate logistic regression was adopted to analyze the risk factors for myocardial injury.ResultsThe occurrence of myocardial injury in Omicron variant-infected geriatric patients was up to 34.07% and these patients may have a higher rate of requiring intensive care (P < 0.05). By comparing myocardial injury patients with non-myocardial injury patients, notable differences were observed in age, pre-existing medical conditions (e.g., hypertension, coronary heart disease, cerebrovascular disease, arrhythmia, chronic kidney disease, and heart failure), and various laboratory biomarkers, including cycle threshold-ORF1ab gene (Ct-ORF1ab), cycle threshold-N gene (Ct-N), white blood cell count, neutrophil (NEUT) count, NEUT%, lymphocyte (LYM) count, LYM%, and D-dimer, interleukin-6, procalcitonin, C-reactive protein, serum amyloid A, total protein, lactate dehydrogenase, aspartate aminotransferase, glomerular filtration rate, blood urea nitrogen, and serum creatinine (sCr) levels (P < 0.05). Furthermore, in the multivariable logistic regression, we identified potential risk factors for myocardial injury in Omicron variant–infected elderly patients, including advanced age, pre-existing coronary artery disease, interleukin-6 > 22.69 pg/ml, procalcitonin > 0.0435 ng/ml, D-dimer > 0.615 mg/L, and sCr > 81.30 μmol/L.ConclusionThis study revealed the clinical characteristics and potential risk factors associated with myocardial injury that enable early diagnosis of myocardial injury in Omicron variant-infected elderly patients, providing important reference indicators for early diagnosis and timely clinical intervention. |
| first_indexed | 2024-03-08T02:02:25Z |
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| id | doaj.art-152ba04fd9774b9db4c077c525f377d8 |
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| language | English |
| last_indexed | 2024-03-08T02:02:25Z |
| publishDate | 2024-02-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-152ba04fd9774b9db4c077c525f377d82024-02-14T04:26:52ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-02-011110.3389/fcvm.2024.12684991268499A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variantXueying Yu0Xiaoguang Li1Shuai Xia2Lu Lu3Jiahui Fan4Ying Wang5Yan Fu6Chen Suo7Qiuhong Man8Lize Xiong9Lize Xiong10Department of Clinical Laboratory, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Thyroid, Breast and Vascular Surgery, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, ChinaKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Epidemiology and Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaIntroductionMyocardial injury in elderly Omicron variant patients is a leading cause of severe disease and death. This study focuses on elucidating the clinical characteristics and potential risk factors associated with myocardial injury in elderly patients infected with the Omicron variant.MethodsMyocardial injury was defined based on elevated cardiac troponin concentrations exceeding the 99th percentile upper reference limit. Among 772 elderly Omicron-infected patients, categorized into myocardial injury (n = 263) and non-myocardial injury (n = 509) groups. The stratified log-rank statistic was used to compare the probability of patients developing intensive care. Receiver operating characteristic curves were used to determine the best cut-off values of clinical and laboratory data for predicting myocardial injury. Univariate and multivariate logistic regression was adopted to analyze the risk factors for myocardial injury.ResultsThe occurrence of myocardial injury in Omicron variant-infected geriatric patients was up to 34.07% and these patients may have a higher rate of requiring intensive care (P < 0.05). By comparing myocardial injury patients with non-myocardial injury patients, notable differences were observed in age, pre-existing medical conditions (e.g., hypertension, coronary heart disease, cerebrovascular disease, arrhythmia, chronic kidney disease, and heart failure), and various laboratory biomarkers, including cycle threshold-ORF1ab gene (Ct-ORF1ab), cycle threshold-N gene (Ct-N), white blood cell count, neutrophil (NEUT) count, NEUT%, lymphocyte (LYM) count, LYM%, and D-dimer, interleukin-6, procalcitonin, C-reactive protein, serum amyloid A, total protein, lactate dehydrogenase, aspartate aminotransferase, glomerular filtration rate, blood urea nitrogen, and serum creatinine (sCr) levels (P < 0.05). Furthermore, in the multivariable logistic regression, we identified potential risk factors for myocardial injury in Omicron variant–infected elderly patients, including advanced age, pre-existing coronary artery disease, interleukin-6 > 22.69 pg/ml, procalcitonin > 0.0435 ng/ml, D-dimer > 0.615 mg/L, and sCr > 81.30 μmol/L.ConclusionThis study revealed the clinical characteristics and potential risk factors associated with myocardial injury that enable early diagnosis of myocardial injury in Omicron variant-infected elderly patients, providing important reference indicators for early diagnosis and timely clinical intervention.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1268499/fullOmicron variantelderlymyocardial injuryclinical characteristicsrisk factors |
| spellingShingle | Xueying Yu Xiaoguang Li Shuai Xia Lu Lu Jiahui Fan Ying Wang Yan Fu Chen Suo Qiuhong Man Lize Xiong Lize Xiong A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant Frontiers in Cardiovascular Medicine Omicron variant elderly myocardial injury clinical characteristics risk factors |
| title | A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant |
| title_full | A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant |
| title_fullStr | A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant |
| title_full_unstemmed | A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant |
| title_short | A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant |
| title_sort | study of clinical and serological correlation of early myocardial injury in elderly patients infected with the omicron variant |
| topic | Omicron variant elderly myocardial injury clinical characteristics risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1268499/full |
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