Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination of <i>TMEM154</i> E35K
Small ruminant lentiviruses (SRLVs) cause maedi-visna disease in sheep and are prevalent in Iran and Germany. The association of the transmembrane protein 154 (TMEM154) variants with SRLV infection has been previously identified by a genome-wide association (GWAS) approach and subsequent analyses, a...
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MDPI AG
2019-09-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/9/9/685 |
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| author | Vahid Molaee Vahid Otarod Darab Abdollahi Gesine Lühken |
| author_facet | Vahid Molaee Vahid Otarod Darab Abdollahi Gesine Lühken |
| author_sort | Vahid Molaee |
| collection | DOAJ |
| description | Small ruminant lentiviruses (SRLVs) cause maedi-visna disease in sheep and are prevalent in Iran and Germany. The association of the transmembrane protein 154 (TMEM154) variants with SRLV infection has been previously identified by a genome-wide association (GWAS) approach and subsequent analyses, and validated in some US, German, and Turkish sheep flocks. We aimed at evaluating these findings for the first time in Iranian, and in some more German sheep flocks/breeds. Also, we aimed at comparing the SRLV susceptibility in Iranian and German sheep based on the frequency of the <i>TMEM154</i> E35 allele. About 800 blood samples were collected from 21 Iranian and German sheep flocks/breeds for different purposes: (1) The association of <i>TMEM154</i> E35K with SRLV infection status was tested in four sheep breeds and found to be significant in Kermani, Merinoland, and Brown Hair. (2) The usefulness of the <i>TMEM154</i> E35 frequency for predicting SRLV susceptibility was evaluated by regression analysis, combining data from this study and some already published data. Results showed a significant association between E35 frequency and SRLV prevalence. (3) SRLV susceptibility was compared based on E35 frequency in Iranian and German sheep. Altogether, findings of this study provide valuable information on SRLV susceptibility, using <i>TMEM154</i> E35, in Iranian and German sheep. |
| first_indexed | 2024-12-20T01:53:12Z |
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| id | doaj.art-152c7c040fb44c91b4278197dd206206 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-12-20T01:53:12Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-152c7c040fb44c91b4278197dd2062062022-12-21T19:57:35ZengMDPI AGAnimals2076-26152019-09-019968510.3390/ani9090685ani9090685Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination of <i>TMEM154</i> E35KVahid Molaee0Vahid Otarod1Darab Abdollahi2Gesine Lühken3Department of Animal Breeding and Genetics, Justus Liebig University Giessen, Ludwigstraße 21, 35390 Gießen, GermanyQuarantine and Biosafety Directorate General, Iran Veterinary Organization (IVO), Vali Asr Avenue, Seyd Jamaledin Asad Abadi Street, 6349 Tehran, IranBureau of Animal Health and Disease Management, Iran Veterinary Organization (IVO), Vali Asr Avenue, Seyd Jamaledin Asad Abadi Street, 6349 Tehran, IranDepartment of Animal Breeding and Genetics, Justus Liebig University Giessen, Ludwigstraße 21, 35390 Gießen, GermanySmall ruminant lentiviruses (SRLVs) cause maedi-visna disease in sheep and are prevalent in Iran and Germany. The association of the transmembrane protein 154 (TMEM154) variants with SRLV infection has been previously identified by a genome-wide association (GWAS) approach and subsequent analyses, and validated in some US, German, and Turkish sheep flocks. We aimed at evaluating these findings for the first time in Iranian, and in some more German sheep flocks/breeds. Also, we aimed at comparing the SRLV susceptibility in Iranian and German sheep based on the frequency of the <i>TMEM154</i> E35 allele. About 800 blood samples were collected from 21 Iranian and German sheep flocks/breeds for different purposes: (1) The association of <i>TMEM154</i> E35K with SRLV infection status was tested in four sheep breeds and found to be significant in Kermani, Merinoland, and Brown Hair. (2) The usefulness of the <i>TMEM154</i> E35 frequency for predicting SRLV susceptibility was evaluated by regression analysis, combining data from this study and some already published data. Results showed a significant association between E35 frequency and SRLV prevalence. (3) SRLV susceptibility was compared based on E35 frequency in Iranian and German sheep. Altogether, findings of this study provide valuable information on SRLV susceptibility, using <i>TMEM154</i> E35, in Iranian and German sheep.https://www.mdpi.com/2076-2615/9/9/685maedi-visnasmall ruminant lentivirussheepsusceptibilitytransmembrane proteinTMEM154 |
| spellingShingle | Vahid Molaee Vahid Otarod Darab Abdollahi Gesine Lühken Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination of <i>TMEM154</i> E35K Animals maedi-visna small ruminant lentivirus sheep susceptibility transmembrane protein TMEM154 |
| title | Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination of <i>TMEM154</i> E35K |
| title_full | Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination of <i>TMEM154</i> E35K |
| title_fullStr | Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination of <i>TMEM154</i> E35K |
| title_full_unstemmed | Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination of <i>TMEM154</i> E35K |
| title_short | Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination of <i>TMEM154</i> E35K |
| title_sort | lentivirus susceptibility in iranian and german sheep assessed by determination of i tmem154 i e35k |
| topic | maedi-visna small ruminant lentivirus sheep susceptibility transmembrane protein TMEM154 |
| url | https://www.mdpi.com/2076-2615/9/9/685 |
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