New Allosteric Modulators of AMPA Receptors: Synthesis and Study of Their Functional Activity by Radioligand-Receptor Binding Analysis

New Allosteric Modulators of AMPA Receptors: Synthesis and Study of Their Functional Activity by Radioligand-Receptor Binding Analysis

The synthetic approaches to three new AMPA receptor modulators—derivatives of 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.1<sup>3,11</sup>]tetradecane-4,8,12-trione—had been developed and all steps of synthesis were optimized. The structures of the compounds contain tricyclic cage and indan...

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Bibliographic Details
Main Authors: Elena A. Golubeva, Mstislav I. Lavrov, Polina N. Veremeeva, Tatiana V. Vyunova, Konstantin V. Shevchenko, Maxim A. Topchiy, Andrey F. Asachenko, Vladimir A. Palyulin
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
AMPA receptor allosteric modulators
CNS pathologies
radioligand binding
[<sup>3</sup>H]PAM-43
cross-coupling reaction
heterogeneous hydrogenation
Online Access:https://www.mdpi.com/1422-0067/24/12/10293

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https://www.mdpi.com/1422-0067/24/12/10293

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