Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span.

Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span.

Vitamin K is a fat-soluble vitamin that plays important roles in blood coagulation and bone metabolism. One of its functions is as a co-factor for γ-glutamyl carboxylase (Ggcx). Conventional knockout of Ggcx causes death shortly after birth in homozygous mice. We created Ggcx-floxed mice by insertin...

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Main Authors: Kotaro Azuma, Tohru Tsukui, Kazuhiro Ikeda, Sachiko Shiba, Kimie Nakagawa, Toshio Okano, Tomohiko Urano, Kuniko Horie-Inoue, Yasuyoshi Ouchi, Masahito Ikawa, Satoshi Inoue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3919827?pdf=render

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