Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran
Introduction: Osteoprotegerin (OPG), a soluble decoy receptor secreted by osteoblasts, binds RANK-L, preventing stimulation of osteoclastogenesis. In the present study we aimed to investigate the impact of OPG variants and susceptibility to childhood acute lymphocytic leukemia (ALL) in a sample of I...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2014-12-01
|
| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/405 |
| _version_ | 1797706029882933248 |
|---|---|
| author | Mohammad Hashemi Mahboubeh Ebrahimi Shadi Amininia Majid Naderi Ebrahim Eskandari-Nasab Mohsen Taheri |
| author_facet | Mohammad Hashemi Mahboubeh Ebrahimi Shadi Amininia Majid Naderi Ebrahim Eskandari-Nasab Mohsen Taheri |
| author_sort | Mohammad Hashemi |
| collection | DOAJ |
| description | Introduction: Osteoprotegerin (OPG), a soluble decoy receptor secreted by osteoblasts, binds RANK-L, preventing stimulation of osteoclastogenesis. In the present study we aimed to investigate the impact of OPG variants and susceptibility to childhood acute lymphocytic leukemia (ALL) in a sample of Iranian population.
Methods: This case-control study was done on 98 ALL and 124 healthy children. We genotyped the polymorphisms using tetra-primer ARMS-PCR (T-ARMS-PCR).
Results: Our findings showed that neither rs3102735 nor rs2073617 variants were associated with ALL in a sample of Iranian population. Concerning rs3102735 polymorphism, the age of ALL predispositions was significantly higher in TC+CC genotype than TT genotype (P=0.032). Furthermore, the CSF involvement was significantly higher in ALL subjects carrying TC+CC genotype (p=0.044).
Conclusion: We found no association between OPG (rs3102735, rs2073617) gene polymorphisms and risk of childhood ALL. Further studies with larger sample sizes and various ethnicities are necessary to verify our findings. |
| first_indexed | 2024-03-12T05:46:11Z |
| format | Article |
| id | doaj.art-152ed535bd5f4a10aab426306c68d19d |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T05:46:11Z |
| publishDate | 2014-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-152ed535bd5f4a10aab426306c68d19d2023-09-03T05:36:13ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072014-12-0184391Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast IranMohammad Hashemi0Mahboubeh Ebrahimi1Shadi Amininia2Majid Naderi3Ebrahim Eskandari-Nasab4Mohsen Taheri5Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. AND Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.Introduction: Osteoprotegerin (OPG), a soluble decoy receptor secreted by osteoblasts, binds RANK-L, preventing stimulation of osteoclastogenesis. In the present study we aimed to investigate the impact of OPG variants and susceptibility to childhood acute lymphocytic leukemia (ALL) in a sample of Iranian population. Methods: This case-control study was done on 98 ALL and 124 healthy children. We genotyped the polymorphisms using tetra-primer ARMS-PCR (T-ARMS-PCR). Results: Our findings showed that neither rs3102735 nor rs2073617 variants were associated with ALL in a sample of Iranian population. Concerning rs3102735 polymorphism, the age of ALL predispositions was significantly higher in TC+CC genotype than TT genotype (P=0.032). Furthermore, the CSF involvement was significantly higher in ALL subjects carrying TC+CC genotype (p=0.044). Conclusion: We found no association between OPG (rs3102735, rs2073617) gene polymorphisms and risk of childhood ALL. Further studies with larger sample sizes and various ethnicities are necessary to verify our findings.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/405Acute lymphocytic leukemiaOPGOsteoprotegerinPolymorphism |
| spellingShingle | Mohammad Hashemi Mahboubeh Ebrahimi Shadi Amininia Majid Naderi Ebrahim Eskandari-Nasab Mohsen Taheri Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran International Journal of Hematology-Oncology and Stem Cell Research Acute lymphocytic leukemia OPG Osteoprotegerin Polymorphism |
| title | Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran |
| title_full | Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran |
| title_fullStr | Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran |
| title_full_unstemmed | Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran |
| title_short | Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran |
| title_sort | evaluation of rs3102735 and rs2073617 osteoprotegerin gene polymorphisms and the risk of childhood acute lymphoblastic leukemia in zahedan southeast iran |
| topic | Acute lymphocytic leukemia OPG Osteoprotegerin Polymorphism |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/405 |
| work_keys_str_mv | AT mohammadhashemi evaluationofrs3102735andrs2073617osteoprotegeringenepolymorphismsandtheriskofchildhoodacutelymphoblasticleukemiainzahedansoutheastiran AT mahboubehebrahimi evaluationofrs3102735andrs2073617osteoprotegeringenepolymorphismsandtheriskofchildhoodacutelymphoblasticleukemiainzahedansoutheastiran AT shadiamininia evaluationofrs3102735andrs2073617osteoprotegeringenepolymorphismsandtheriskofchildhoodacutelymphoblasticleukemiainzahedansoutheastiran AT majidnaderi evaluationofrs3102735andrs2073617osteoprotegeringenepolymorphismsandtheriskofchildhoodacutelymphoblasticleukemiainzahedansoutheastiran AT ebrahimeskandarinasab evaluationofrs3102735andrs2073617osteoprotegeringenepolymorphismsandtheriskofchildhoodacutelymphoblasticleukemiainzahedansoutheastiran AT mohsentaheri evaluationofrs3102735andrs2073617osteoprotegeringenepolymorphismsandtheriskofchildhoodacutelymphoblasticleukemiainzahedansoutheastiran |