The skin through reflectance confocal microscopy -Historical background, technical principles, and its correlation with histopathology
Abstract Since its first introduction into medical practice, reflectance confocal microscopy (RCM) has been a valuable non-invasive diagnostic tool for the assessment of benign and malignant neoplasms of the skin. It has also been used as an adjunct for diagnosing equivocal cutaneous neoplasms that...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Dermatologia
2022-11-01
|
| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600697&lng=en&tlng=en |
| _version_ | 1811220579736354816 |
|---|---|
| author | Naiara Fraga Braghiroli Samantha Sugerik Luiz Antônio Rodrigues de Freitas Margaret Oliviero Harold Rabinovitz |
| author_facet | Naiara Fraga Braghiroli Samantha Sugerik Luiz Antônio Rodrigues de Freitas Margaret Oliviero Harold Rabinovitz |
| author_sort | Naiara Fraga Braghiroli |
| collection | DOAJ |
| description | Abstract Since its first introduction into medical practice, reflectance confocal microscopy (RCM) has been a valuable non-invasive diagnostic tool for the assessment of benign and malignant neoplasms of the skin. It has also been used as an adjunct for diagnosing equivocal cutaneous neoplasms that lack characteristic clinical or dermoscopic features. The use of RCM has led to a decreased number of biopsies of benign lesions. Multiple published studies show a strong correlation between RCM and histopathology thereby creating a bridge between clinical aspects, dermoscopy, and histopathology. Dermatopathologists may potentially play an important role in the interpretation of confocal images, by their ability to correlate histopathologic findings. RCM has also been shown to be an important adjunct to delineating tumoral margins during surgery, as well as for monitoring the non-surgical treatment of skin cancers. Advanced technology with smaller probes, such as the VivaScope 3000, has allowed access to lesions in previously inaccessible anatomic locations. This review explains the technical principles of RCM and describes the most common RCM features of normal skin with their corresponding histological correlation. |
| first_indexed | 2024-04-12T07:44:09Z |
| format | Article |
| id | doaj.art-152faf552e48487bbd37914487191e7b |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-12T07:44:09Z |
| publishDate | 2022-11-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-152faf552e48487bbd37914487191e7b2022-12-22T03:41:45ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962022-11-0197669770310.1016/j.abd.2021.10.010The skin through reflectance confocal microscopy -Historical background, technical principles, and its correlation with histopathologyNaiara Fraga Braghirolihttps://orcid.org/0000-0002-7444-3678Samantha Sugerikhttps://orcid.org/0000-0002-5737-456XLuiz Antônio Rodrigues de Freitashttps://orcid.org/0000-0001-5499-9858Margaret Olivierohttps://orcid.org/0000-0001-5970-4916Harold Rabinovitzhttps://orcid.org/0000-0001-6895-9697Abstract Since its first introduction into medical practice, reflectance confocal microscopy (RCM) has been a valuable non-invasive diagnostic tool for the assessment of benign and malignant neoplasms of the skin. It has also been used as an adjunct for diagnosing equivocal cutaneous neoplasms that lack characteristic clinical or dermoscopic features. The use of RCM has led to a decreased number of biopsies of benign lesions. Multiple published studies show a strong correlation between RCM and histopathology thereby creating a bridge between clinical aspects, dermoscopy, and histopathology. Dermatopathologists may potentially play an important role in the interpretation of confocal images, by their ability to correlate histopathologic findings. RCM has also been shown to be an important adjunct to delineating tumoral margins during surgery, as well as for monitoring the non-surgical treatment of skin cancers. Advanced technology with smaller probes, such as the VivaScope 3000, has allowed access to lesions in previously inaccessible anatomic locations. This review explains the technical principles of RCM and describes the most common RCM features of normal skin with their corresponding histological correlation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600697&lng=en&tlng=enMicroscopy, confocalPathologySkin neoplasmSkin abnormalities |
| spellingShingle | Naiara Fraga Braghiroli Samantha Sugerik Luiz Antônio Rodrigues de Freitas Margaret Oliviero Harold Rabinovitz The skin through reflectance confocal microscopy -Historical background, technical principles, and its correlation with histopathology Anais Brasileiros de Dermatologia Microscopy, confocal Pathology Skin neoplasm Skin abnormalities |
| title | The skin through reflectance confocal microscopy -Historical background, technical principles, and its correlation with histopathology |
| title_full | The skin through reflectance confocal microscopy -Historical background, technical principles, and its correlation with histopathology |
| title_fullStr | The skin through reflectance confocal microscopy -Historical background, technical principles, and its correlation with histopathology |
| title_full_unstemmed | The skin through reflectance confocal microscopy -Historical background, technical principles, and its correlation with histopathology |
| title_short | The skin through reflectance confocal microscopy -Historical background, technical principles, and its correlation with histopathology |
| title_sort | skin through reflectance confocal microscopy historical background technical principles and its correlation with histopathology |
| topic | Microscopy, confocal Pathology Skin neoplasm Skin abnormalities |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600697&lng=en&tlng=en |
| work_keys_str_mv | AT naiarafragabraghiroli theskinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT samanthasugerik theskinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT luizantoniorodriguesdefreitas theskinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT margaretoliviero theskinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT haroldrabinovitz theskinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT naiarafragabraghiroli skinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT samanthasugerik skinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT luizantoniorodriguesdefreitas skinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT margaretoliviero skinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology AT haroldrabinovitz skinthroughreflectanceconfocalmicroscopyhistoricalbackgroundtechnicalprinciplesanditscorrelationwithhistopathology |