Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were di...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto de Tecnologia do Paraná (Tecpar)
2012-08-01
|
| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007 |
| _version_ | 1819062037389508608 |
|---|---|
| author | Danielle Ayr Tavares de Almeida Camila Pereira Braga Ethel Lourenzi Barbosa Novelli Ana Angélica Henrique Fernandes |
| author_facet | Danielle Ayr Tavares de Almeida Camila Pereira Braga Ethel Lourenzi Barbosa Novelli Ana Angélica Henrique Fernandes |
| author_sort | Danielle Ayr Tavares de Almeida |
| collection | DOAJ |
| description | The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. |
| first_indexed | 2024-12-21T14:52:24Z |
| format | Article |
| id | doaj.art-153043b7cf77405385cfbf1e301dc3ec |
| institution | Directory Open Access Journal |
| issn | 1516-8913 1678-4324 |
| language | English |
| last_indexed | 2024-12-21T14:52:24Z |
| publishDate | 2012-08-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-153043b7cf77405385cfbf1e301dc3ec2022-12-21T18:59:51ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1516-89131678-43242012-08-0155452753610.1590/S1516-89132012000400007Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitaminDanielle Ayr Tavares de AlmeidaCamila Pereira BragaEthel Lourenzi Barbosa NovelliAna Angélica Henrique FernandesThe present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007vitamin Elipid profileoxidative stressSTZ |
| spellingShingle | Danielle Ayr Tavares de Almeida Camila Pereira Braga Ethel Lourenzi Barbosa Novelli Ana Angélica Henrique Fernandes Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin Brazilian Archives of Biology and Technology vitamin E lipid profile oxidative stress STZ |
| title | Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
| title_full | Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
| title_fullStr | Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
| title_full_unstemmed | Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
| title_short | Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
| title_sort | evaluation of lipid profile and oxidative stress in stz induced rats treated with antioxidant vitamin |
| topic | vitamin E lipid profile oxidative stress STZ |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007 |
| work_keys_str_mv | AT danielleayrtavaresdealmeida evaluationoflipidprofileandoxidativestressinstzinducedratstreatedwithantioxidantvitamin AT camilapereirabraga evaluationoflipidprofileandoxidativestressinstzinducedratstreatedwithantioxidantvitamin AT ethellourenzibarbosanovelli evaluationoflipidprofileandoxidativestressinstzinducedratstreatedwithantioxidantvitamin AT anaangelicahenriquefernandes evaluationoflipidprofileandoxidativestressinstzinducedratstreatedwithantioxidantvitamin |