Characterization of the skin keloid microenvironment
Abstract Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids exhibit some cancer-like behaviors, with similar genetic and epigenetic modifications in the keloid microenvironment. The keloid microenvironment is composed of keratinocytes, fibroblasts, myofibrobl...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01214-0 |
| _version_ | 1797557671292829696 |
|---|---|
| author | Mengwen Zhang Hailong Chen Huan Qian Chen Wang |
| author_facet | Mengwen Zhang Hailong Chen Huan Qian Chen Wang |
| author_sort | Mengwen Zhang |
| collection | DOAJ |
| description | Abstract Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids exhibit some cancer-like behaviors, with similar genetic and epigenetic modifications in the keloid microenvironment. The keloid microenvironment is composed of keratinocytes, fibroblasts, myofibroblasts, vascular endothelial cells, immune cells, stem cells and collagen fibers. Recent advances in the study of keloids have led to novel insights into cellular communication among components of the keloid microenvironment as well as potential therapeutic targets for treating keloids. In this review, we summarized the nature of genetic and epigenetic regulation in keloid-derived fibroblasts, epithelial-to-mesenchymal transition of keratinocytes, immune cell infiltration into keloids, the differentiation of keloid-derived stem cells, endothelial-to-mesenchymal transition of vascular endothelial cells, extracellular matrix synthesis and remodeling, and uncontrolled angiogenesis in keloids with the aim of identifying new targets for therapeutic benefit. Video Abstract |
| first_indexed | 2024-03-10T17:19:58Z |
| format | Article |
| id | doaj.art-1532839210a44e878e7630c3491bcf3b |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-10T17:19:58Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-1532839210a44e878e7630c3491bcf3b2023-11-20T10:22:03ZengBMCCell Communication and Signaling1478-811X2023-08-0121111110.1186/s12964-023-01214-0Characterization of the skin keloid microenvironmentMengwen Zhang0Hailong Chen1Huan Qian2Chen Wang3The Second Affiliated Hospital of Zhejiang University School of MedicineThe Second Affiliated Hospital of Zhejiang University School of MedicineThe Second Affiliated Hospital of Zhejiang University School of MedicineThe Second Affiliated Hospital of Zhejiang University School of MedicineAbstract Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids exhibit some cancer-like behaviors, with similar genetic and epigenetic modifications in the keloid microenvironment. The keloid microenvironment is composed of keratinocytes, fibroblasts, myofibroblasts, vascular endothelial cells, immune cells, stem cells and collagen fibers. Recent advances in the study of keloids have led to novel insights into cellular communication among components of the keloid microenvironment as well as potential therapeutic targets for treating keloids. In this review, we summarized the nature of genetic and epigenetic regulation in keloid-derived fibroblasts, epithelial-to-mesenchymal transition of keratinocytes, immune cell infiltration into keloids, the differentiation of keloid-derived stem cells, endothelial-to-mesenchymal transition of vascular endothelial cells, extracellular matrix synthesis and remodeling, and uncontrolled angiogenesis in keloids with the aim of identifying new targets for therapeutic benefit. Video Abstracthttps://doi.org/10.1186/s12964-023-01214-0Keloid microenvironmentKeloid-derived fibroblastsKeratinocytesVascular endothelial cellsImmune cellsStem cells |
| spellingShingle | Mengwen Zhang Hailong Chen Huan Qian Chen Wang Characterization of the skin keloid microenvironment Cell Communication and Signaling Keloid microenvironment Keloid-derived fibroblasts Keratinocytes Vascular endothelial cells Immune cells Stem cells |
| title | Characterization of the skin keloid microenvironment |
| title_full | Characterization of the skin keloid microenvironment |
| title_fullStr | Characterization of the skin keloid microenvironment |
| title_full_unstemmed | Characterization of the skin keloid microenvironment |
| title_short | Characterization of the skin keloid microenvironment |
| title_sort | characterization of the skin keloid microenvironment |
| topic | Keloid microenvironment Keloid-derived fibroblasts Keratinocytes Vascular endothelial cells Immune cells Stem cells |
| url | https://doi.org/10.1186/s12964-023-01214-0 |
| work_keys_str_mv | AT mengwenzhang characterizationoftheskinkeloidmicroenvironment AT hailongchen characterizationoftheskinkeloidmicroenvironment AT huanqian characterizationoftheskinkeloidmicroenvironment AT chenwang characterizationoftheskinkeloidmicroenvironment |