A comprehensive study on signal transduction and therapeutic role of miR-877 in human cancers
MicroRNAs are a group of short non-coding RNAs (miRNAs), which are epigenetically involved in gene expression and other cellular biological processes and can be considered as potential biomarkers for cancer detection and support for treatment management. This review aims to amass the evidence in ord...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=118;epage=118;aulast=Rafat |
| _version_ | 1797649549555138560 |
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| author | Milad Rafat Mahdis Kohsarian Mohamad Bahiraei Amin R Nikpoor |
| author_facet | Milad Rafat Mahdis Kohsarian Mohamad Bahiraei Amin R Nikpoor |
| author_sort | Milad Rafat |
| collection | DOAJ |
| description | MicroRNAs are a group of short non-coding RNAs (miRNAs), which are epigenetically involved in gene expression and other cellular biological processes and can be considered as potential biomarkers for cancer detection and support for treatment management. This review aims to amass the evidence in order to reach the molecular mechanism and clinical significance of miR-877 in different types of cancer. Dysregulation of miR-877 level in various types of malignancies as bladder cancer, cervical cancer, cholangiocarcinoma, colorectal cancer (CRC), gastric cancer, glioblastoma, head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, laryngeal squamous cell carcinoma, melanoma, non-small cell lung cancer (NSCLC), oral squamous cell carcinoma, ovarian cancer (OC), pancreatic ductal adenocarcinoma, and renal cell carcinoma (RCC) have reported, significantly increase or decrease in its level, which can be indicated to its function as oncogene or tumor suppressor. MiR-877 is involved in cell proliferation, migration, and invasion through cell cycle pathways in cancer. MiR-877 could be potential a candidate as a valuable biomarker for prognosis in various cancers. Through this study, we proposed that miR-877 can potentially be a candidate as a prognostic marker for early detection of tumor development, progression, as well as metastasis. |
| first_indexed | 2024-03-11T15:47:42Z |
| format | Article |
| id | doaj.art-1534ffe09d2541a09f101f2be7782972 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 |
| language | English |
| last_indexed | 2024-03-11T15:47:42Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-1534ffe09d2541a09f101f2be77829722023-10-26T05:43:17ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752023-01-0112111811810.4103/abr.abr_412_21A comprehensive study on signal transduction and therapeutic role of miR-877 in human cancersMilad RafatMahdis KohsarianMohamad BahiraeiAmin R NikpoorMicroRNAs are a group of short non-coding RNAs (miRNAs), which are epigenetically involved in gene expression and other cellular biological processes and can be considered as potential biomarkers for cancer detection and support for treatment management. This review aims to amass the evidence in order to reach the molecular mechanism and clinical significance of miR-877 in different types of cancer. Dysregulation of miR-877 level in various types of malignancies as bladder cancer, cervical cancer, cholangiocarcinoma, colorectal cancer (CRC), gastric cancer, glioblastoma, head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, laryngeal squamous cell carcinoma, melanoma, non-small cell lung cancer (NSCLC), oral squamous cell carcinoma, ovarian cancer (OC), pancreatic ductal adenocarcinoma, and renal cell carcinoma (RCC) have reported, significantly increase or decrease in its level, which can be indicated to its function as oncogene or tumor suppressor. MiR-877 is involved in cell proliferation, migration, and invasion through cell cycle pathways in cancer. MiR-877 could be potential a candidate as a valuable biomarker for prognosis in various cancers. Through this study, we proposed that miR-877 can potentially be a candidate as a prognostic marker for early detection of tumor development, progression, as well as metastasis.http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=118;epage=118;aulast=Rafatbiomarkercancermicrornamicrorna-877mir-877 |
| spellingShingle | Milad Rafat Mahdis Kohsarian Mohamad Bahiraei Amin R Nikpoor A comprehensive study on signal transduction and therapeutic role of miR-877 in human cancers Advanced Biomedical Research biomarker cancer microrna microrna-877 mir-877 |
| title | A comprehensive study on signal transduction and therapeutic role of miR-877 in human cancers |
| title_full | A comprehensive study on signal transduction and therapeutic role of miR-877 in human cancers |
| title_fullStr | A comprehensive study on signal transduction and therapeutic role of miR-877 in human cancers |
| title_full_unstemmed | A comprehensive study on signal transduction and therapeutic role of miR-877 in human cancers |
| title_short | A comprehensive study on signal transduction and therapeutic role of miR-877 in human cancers |
| title_sort | comprehensive study on signal transduction and therapeutic role of mir 877 in human cancers |
| topic | biomarker cancer microrna microrna-877 mir-877 |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=118;epage=118;aulast=Rafat |
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