Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs n...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07538-7 |
| _version_ | 1818990684647981056 |
|---|---|
| author | Toni Celià-Terrassa Caleb Bastian Daniel D. Liu Brian Ell Nicole M. Aiello Yong Wei Jose Zamalloa Andres M. Blanco Xiang Hang Dmitriy Kunisky Wenyang Li Elizabeth D. Williams Herschel Rabitz Yibin Kang |
| author_facet | Toni Celià-Terrassa Caleb Bastian Daniel D. Liu Brian Ell Nicole M. Aiello Yong Wei Jose Zamalloa Andres M. Blanco Xiang Hang Dmitriy Kunisky Wenyang Li Elizabeth D. Williams Herschel Rabitz Yibin Kang |
| author_sort | Toni Celià-Terrassa |
| collection | DOAJ |
| description | The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs negative feedback loop and enhances metastasis. |
| first_indexed | 2024-12-20T19:58:17Z |
| format | Article |
| id | doaj.art-15369d2c47794345b6112dc4b6b051de |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T19:58:17Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-15369d2c47794345b6112dc4b6b051de2022-12-21T19:28:07ZengNature PortfolioNature Communications2041-17232018-11-019111210.1038/s41467-018-07538-7Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic abilityToni Celià-Terrassa0Caleb Bastian1Daniel D. Liu2Brian Ell3Nicole M. Aiello4Yong Wei5Jose Zamalloa6Andres M. Blanco7Xiang Hang8Dmitriy Kunisky9Wenyang Li10Elizabeth D. Williams11Herschel Rabitz12Yibin Kang13Department of Molecular Biology, Princeton UniversityProgram in Applied and Computational Mathematics, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Mathematics, Princeton UniversityDepartment of Molecular Biology, Princeton UniversitySchool of Biomedical Sciences, Queensland University of Technology (QUT), Translational Research InstituteProgram in Applied and Computational Mathematics, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityThe epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs negative feedback loop and enhances metastasis.https://doi.org/10.1038/s41467-018-07538-7 |
| spellingShingle | Toni Celià-Terrassa Caleb Bastian Daniel D. Liu Brian Ell Nicole M. Aiello Yong Wei Jose Zamalloa Andres M. Blanco Xiang Hang Dmitriy Kunisky Wenyang Li Elizabeth D. Williams Herschel Rabitz Yibin Kang Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability Nature Communications |
| title | Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability |
| title_full | Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability |
| title_fullStr | Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability |
| title_full_unstemmed | Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability |
| title_short | Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability |
| title_sort | hysteresis control of epithelial mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability |
| url | https://doi.org/10.1038/s41467-018-07538-7 |
| work_keys_str_mv | AT toniceliaterrassa hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT calebbastian hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT danieldliu hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT brianell hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT nicolemaiello hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT yongwei hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT josezamalloa hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT andresmblanco hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT xianghang hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT dmitriykunisky hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT wenyangli hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT elizabethdwilliams hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT herschelrabitz hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability AT yibinkang hysteresiscontrolofepithelialmesenchymaltransitiondynamicsconveysadistinctprogramwithenhancedmetastaticability |